MIF molecular target information overview
Overview of MIF molecular targets
Macrophage migration inhibitory factor (MIF) is an important regulator of innate immunity. Bacterial antigens stimulate leukocytes to release MIF into the bloodstream. Circulating MIF binds to CD74 on other immune cells to initiate acute immune responses, making MIF an inflammatory cytokine. In addition, glucocorticoids can stimulate the release of MIF from leukocytes. MIF modulates the function of macrophages in host defense by inhibiting the anti-inflammatory effects of glucocorticoids. MIF is an inflammatory mediator associated with the severity of rheumatoid arthritis. MIF protein levels are increased in the plasma of patients with schizophrenia, including in the early stages of the disease, but the clinical significance of this phenomenon has not been determined. MIF also induces cardiac changes during sepsis. In addition, there is evidence of a relationship between MIF production and the metastatic potential of colon cancer.
Human MIF molecular target information
Molecular name:MIF, macrophage migration inhibitory factor
Alias:
- GIF
- GLIF
- L-dopachrome isomerase
- L-dopachrome tautomerase
- macrophage migration inhibitory factor (glycosylation-inhibiting factor)
- MMIF
- phenylpyruvate tautomerase
Gene sequence:NCBI_Gene: 4282
Protein sequence:UniProtKB: P14174
Human MIF target molecular function (prediction)
Enables several functions, including identical protein binding activity; intramolecular oxidoreductase activity; and receptor ligand activity. Involved in several processes, including positive regulation of cell population proliferation; positive regulation of protein phosphorylation; and regulation of intracellular signal transduction. Located in several cellular components, including cell surface; extracellular space; disease (multiple); asthma; lung disease (multiple); obesity; and rhinitis.
Mouse Mif molecular target information
Molecular name:Mif, macrophage migration inhibitory factor (glycosylation-inhibiting factor)
Alias:
- Glif
- glycosylation inhibiting factor
Gene sequence:NCBI_Gene: 17319
Protein sequence:
Mouse Mif target molecular function (prediction)
Acts upstream of or within DNA damage response, signal transduction by p53 class mediator; cell aging; and regulation of cell population proliferation. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in allergic disease; asthma; cystic fibrosis; lung disease (multiple); and obesity. Orthologous to human MIF (macrophage migration inhibitory factor).
Rat Mif molecular target information
Molecular name:Mif, macrophage migration inhibitory factor
Alias:
- glutathione-binding 13 kDa protein
- L-dopachrome isomerase
- L-dopachrome tautomerase
- LOC103694877
- macrophage migration inhibitory factor (glycosylation-inhibiting factor)
- MGC72801
- phenylpyruvate tautomerase
Gene sequence:NCBI_Gene: 81683
Protein sequence:
Rat Mif target molecular function (prediction)
Predicted to enable several functions, including identical protein binding activity; intramolecular oxidoreductase activity; and receptor ligand activity. Involved in several processes, including positive regulation of transport; response to steroid hormone; and response to vitamin. Located in cytoplasm; extracellular space; and nucleus. Used to study several diseases, including acute necrotizing pancreatitis; cardiomyopathy (multiple); lung disease (multiple); retinitis; and toxic shock syndrome. Biomarker of borna disease; cystitis; kidney disease; myocardial infarction; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in allergic disease; asthma; cystic fibrosis; lung disease (multiple); and obesity. Orthologous to human MIF (macrophage migration inhibitory factor).