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CXCL13 molecular target information overview


  • Molecular name: CXCL13, CXC motif chemokine ligand 13
  • Gene family: Chemokine ligands
  • Alias: BLC; BCA-1; BLR1L; ANGIE; ANGIE2
  • Former name: SCYB13
  • Alias: B-cell chemoattractant; small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cell chemoattractant); chemokine (CXC motif) ligand 13


    • CXCL13 molecular target review


    Chemokine CXC ligand 13 (CXCL13), also known as B lymphocyte chemoattractant (BLC) or BCA-1, is expressed at high levels in the human liver, spleen, lymph nodes, and intestine. It selectively chemotacticizes B cells belonging to the B-1 and B-2 subsets and exerts its function by interacting with the chemokine receptor CXCR5. CXCL13 and its receptor CXCR5 regulate B cell architecture in lymphoid tissue follicles. In T cells, CXCL13 expression is thought to reflect the origin of T cells, especially follicular helper T cells (Tfh) germinal centers. Therefore, the expression of CXCL13 in T cell lymphomas, such as angioimmunoblastic T cell lymphoma, is thought to reflect the origin of tumor T cell germinal centers.


    Human CXCL13 Molecular Target Information


    Molecular name: CXCL13, CXC motif chemokine ligand 13


    Alias:

    • ANGIE
    • ANGIE2
    • b cell-attracting chemokine 1
    • b lymphocyte chemoattractant
    • B-cell chemoattractant
    • B-cell-attracting chemokine 1
    • B-cell-homing chemokine (ligand for Burkitt's lymphoma receptor-1)
    • B-lymphocyte chemoattractant
    • BCA-1
    • BCA1
    • BLC
    • BLR1L
    • CXC motif chemokine 13
    • chemokine (CXC motif) ligand 13 (B-cell chemoattractant)
    • CXC chemokine BLC
    • SCYB13
    • small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cell chemoattractant)
    • small-inducible cytokine B13

    Gene sequence:NCBI_Gene: 10563

    Protein sequence:UniProtKB: O43927


    Human CXCL13 target molecular function (prediction)


    Enables chemokine receptor binding activity; fibroblast growth factor binding activity; and heparin binding activity. Involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; cell chemotaxis; and regulation of chemotaxis. Located in extracellular region.


    Mouse Cxcl13 molecular target information


    Molecular name: Cxcl13, chemokine (CXC motif) ligand 13


    Alternate names:

    • 4631412M08Rik
    • ANGIE2
    • BCA-1
    • BLC
    • RIKEN cDNA 4631412M08 gene
    • Scyb13
    • small inducible cytokine subfamily B (Cys-X-Cys), member 13


    Gene sequence:NCBI_Gene: 55985

    Protein sequence:


    Mouse Cxcl13 target molecular function (prediction)


    Enables CXCR5 chemokine receptor binding activity and chemokine activity. Involved in several processes, including B cell chemotaxis across high endothelial venule; activation of GTPase activity; and lymph node development. Located in extracellular space. Is expressed in Peyer's patch; aorta; central nervous system; and retina. Orthologous to human CXCL13 (CXC motif chemokine ligand 13).


    Rat Cxcl13 molecular target information


    Molecular name: Cxcl13, CXC motif chemokine ligand 13

    Alias:

    • CXC motif chemokine 13
    • chemokine (CXC motif) ligand 13
    • LOC498335
    • similar to Small inducible cytokine B13 precursor (CXCL13) (B lymphocyte chemoattractant) (CXC chemokine BLC)

    Gene sequence:NCBI_Gene: 498335

    Protein sequence:


    Rat Cxcl13 target molecular function (prediction)


    Predicted to enable chemokine receptor binding activity; fibroblast growth factor binding activity; and heparin binding activity. Predicted to be involved in several processes, including cell chemotaxis; regulation of chemotaxis; and response to bacterium. Predicted to act upstream of or within lymph node development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human CXCL13 (CXC motif chemokine ligand 13).