TFRC molecular target information overview
Overview of TFRC molecular targets
Transferrin receptor CD71 is a 1180 kDa type II transmembrane protein that exists as a homodimer on the cell surface and is essential for cell growth. CD71 is expressed in immature, proliferating cells and at lower levels in resting, mature lymphocytes. T cells and B cells stimulated by antigens or mitogens can upregulate the expression of CD71.
Human TFRC molecular target information
Molecular name: TFRC, transferrin receptor
Alias:
- CD71
- IMD46
- p90
- T9
- TFR
- TFR1
- TR
- transferrin receptor (p90, CD71)
- transferrin receptor protein 1
- TRFR
Gene sequence:NCBI_Gene: 7037
Protein sequence:UniProtKB: P02786
Human TFRC target molecular function (prediction)
Acts upstream of or within cellular response to xenobiotic stimulus. Located in several cellular components, including basolateral plasma membrane; clathrin-coated pit; and endosome. Is integral component of plasma membrane. Part of HFE-transferrin receptor complex. Implicated in breast carcinoma; immunodeficiency 46; multiple myeloma; and ovarian cancer. Biomarker of breast cancer; carcinoma (multiple); iron deficiency anemia; and prostate cancer.
Mouse Tfrc molecular target information
Molecule name: Tfrc, transferrin receptor
Alias:
- 2610028K12Rik
- AI195355
- AI426448
- AU015758
- CD71
- E430033M20Rik
- expressed sequence AI195355
- expressed sequence AI426448
- expressed sequence AU015758
- mammary tumor receptor virus 1
- Mtvr-1
- Mtvr1
- p90
- RIKEN cDNA 2610028K12 gene
- RIKEN cDNA E430033M20 gene
- TfR1
- Trfr
Gene sequence:NCBI_Gene: 22042
Protein sequence:
Mouse Tfrc target molecular function (prediction)
Predicted to enable several functions, including Hsp70 protein binding activity; chaperone binding activity; and protein homodimerization activity. Involved in osteoclast differentiation; positive regulation of bone resorption; and positive of lymphocyte proliferation. Acts upstream of or within cellular iron ion homeostasis regulations and cellular response to leukemia inhibitory factor. Located in several cellular components, including clathrin-coated pit; endosome; and extracellular exosome. Part of HFE-transferrin receptor complex. Is expressed in several structures, including alimentary system; extraembryonic component; liver; lung; and meninges. Human ortholog(s) of this gene implicated in breast carcinoma; immunodeficiency 46; multiple myeloma; and ovarian cancer. Orthologous to human TFRC (transferrin receptor).
Rat Tfrc molecular target information
Molecule name: Tfrc, transferrin receptor
Alias:
- tfR
- tfR1
- TR
- transferrin receptor protein 1
- Trfr
Gene sequence:NCBI_Gene: 64678
Protein sequence:
Rat Tfrc target molecular function (prediction)
Enables Hsp70 protein binding activity; chaperone binding activity; and transferrin receptor activity. Involved in several processes, including response to copper ion; response to manganese ion; and response to retinoic acid. Located in several cellular components, including cell surface; extracellular exosome; and recycling endosome membrane. Biomarker of duodenal ulcer; hepatocellular carcinoma; muscular atrophy; non-alcoholic fatty liver disease; and nutrition disease. Human ortholog(s) of this gene implicated in breast carcinoma; immunodeficiency 46; multiple myeloma; and ovarian cancer. Orthologous to human TFRC (transferrin receptor).