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CXCL12 molecular target information overview


  • Molecular name: CXCL12, CXC motif chemokine ligand 12
  • Gene family: Chemokine ligands
  • Alias: SCYB12; SDF-1a; SDF-1b; PBSF; TLSF-a; TLSF-b; TPAR1
  • Former names: SDF1A; SDF1B; SDF1
  • Alias: stromal cell-derived factor 1; chemokine (CXC motif) ligand 12


    • CXCL12 molecular target review


    Chemokine CXC ligand 12 (CXCL12), also known as stromal cell-derived factor 1 (SDF-1), is a chemokine protein that activates leukocytes and is usually induced by proinflammatory stimuli such as LPS, TNF, or IL-1. CXCL12 has a strong chemotactic effect on lymphocytes. During embryogenesis, it promotes the migration of hematopoietic cells from the fetal liver to the bone marrow and the formation of large blood vessels. In adults, CXCL12 plays an important role in angiogenesis, recruiting endothelial progenitor cells (EPCs) in the bone marrow through a CXCR4-dependent mechanism. CXCL12 also plays a role in tumor metastasis, and cancer cells expressing the CXCR4 receptor can be attracted to target tissues. However, in breast cancer, increased CXCL12 expression indicates a reduced risk of distant metastasis.


    Human CXCL12 Molecular Target Information


    Molecular name: CXCL12, CXC motif chemokine ligand 12


    Alias:

    • chemokine (CXC motif) ligand 12
    • intercrine reduced in hepatomas
    • IRH
    • PBSF
    • pre-B cell growth-stimulating factor
    • SCYB12
    • SDF-1a
    • SDF-1b
    • SDF1
    • SDF1A
    • SDF1B
    • stromal cell-derived factor 1
    • TLSF
    • TLSF-a
    • TLSF-b
    • TPAR1

    Gene sequence:NCBI_Gene: 6387

    Protein sequence:UniProtKB: P48061


    Human CXCL12 target molecular function (prediction)


    Enables CXCR chemokine receptor binding activity; chemokine activity; and integrin binding activity. Involved in several processes, including integrin activation; negative regulation of apoptotic process; and of leukocyte migration. Acts upstream of or within positive regulation of T cell migration and positive regulation regulation of cell adhesion. Located in extracellular exosome. Part of collagen-containing extracellular matrix. Implicated in breast carcinoma; diabetic angiopathy; human immunodeficiency virus infectious disease; and type 1 diabetes mellitus. Biomarker of diabetic retinopathy; insulinoma; periodontitis; and type 2 diabetes mellitus.


    Mouse Cxcl12 molecular target information


    Molecular name: Cxcl12, chemokine (CXC motif) ligand 12


    Alias:

    • AI174028
    • expressed sequence AI174028
    • PBSF
    • PBSF/SDF-1
    • Scyb12
    • SDF-1
    • Sdf1
    • Sdf1a
    • Sdf1b
    • stromal cell derived factor 1
    • stromal cell derived factor 1A
    • stromal cell derived factor 1B
    • TLSF-a
    • TLSF-b
    • TPAR1


    Gene sequence:NCBI_Gene: 20315

    Protein sequence:


    Mouse Cxcl12 target molecular function (prediction)


    Enables chemokine activity. Involved in dopaminergic neuron differentiation. Acts upstream of or within several processes, including gamete generation; nervous system development; and positive regulation of intracellular signal transduction. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in breast carcinoma; infectious disease; and type 1 diabetes mellitus. Orthologous to human CXCL12 (CXC motif chemokine ligand 12).


    Rat Cxcl12 molecular target information


    Molecular name: Cxcl12, CXC motif chemokine ligand 12

    Alias:

    • chemokine (CXC motif) ligand 12
    • chemokine (CXC motif) ligand 12 (stromal cell-derived factor 1)
    • SDF-1 gamma
    • Sdf1
    • Stromal cell-derived factor 1
    • stromal cell-derived factor-1 gamma

    Gene sequence:NCBI_Gene: 24772

    Protein sequence:


    Rat Cxcl12 target molecular function (prediction)


    Predicted to enable CXCR chemokine receptor binding activity; chemokine activity; and integrin binding activity. Involved in several processes, including detection of stimulus involved in sensory perception of pain; nervous system development; and regulation of ion transport. Located in several cellular components, including extracellular space; nucleus; and plasma membrane. Used to study myocardial infarction. Biomarker of anti-basement membrane glomerulonephritis; brain ischemia; myocardial infarction; status epilepticus; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in breast carcinoma; diabetic angiopathy; human immunodeficiency virus infectious disease; and type 1 diabetes mellitus. Orthologous to human CXCL12 (CXC motif chemokine ligand 12).