IL10 molecular target information overview
Overview of IL10 molecular targets
Interleukin 10 (IL-10) is a homodimer composed of two 178 amino acid subunits. In humans, it is encoded by the IL-10 gene located on chromosome 1 and consists of five exons. IL-10 is mainly secreted by monocytes, with less secretion by lymphocytes, type II helper T cells (Th2), mast cells, CD4+CD25+Foxp3+ regulatory T cells, and partially activated T cells and B cells. It has multiple effects on immune regulation and inflammation. It downregulates Th1 cytokines, class II MHC antigens, and co-stimulatory molecules of macrophages. It also enhances B cell survival, proliferation, and antibody secretion. IL-10 can block NF-κB activity and participate in the regulation of the JAK-STAT signaling pathway. The immunosuppressive properties of IL-10 suggest that it may be used clinically to inhibit rejection after organ transplantation. IL-10 also has strong anti-inflammatory properties.
Human IL10 Molecular Target Information
Molecular name: IL10, interleukin 10
Alias:
- CSIF
- cytokine synthesis inhibitory factor
- GVHDS
- IL-10
- IL10A
- interleukin-10
- MGC126450
- MGC126451
- T-cell growth inhibitory factor
- TGIF
Gene sequence:NCBI_Gene: 3586
Protein sequence:UniProtKB: P22301
Human IL10 target molecular function (prediction)
Acts upstream of or within several processes, including negative regulation of B cell proliferation; positive regulation of B cell apoptotic process; and positive regulation of signaling receptor activity. Located in extracellular space. Implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Biomarker of several diseases, including autoimmune disease (multiple); diabetes mellitus (multiple); eye disease (multiple); female reproductive organ cancer (multiple); and hematologic cancer (multiple).
Mouse Il10 molecular target information
Molecular name: Il10, interleukin 10
Alternate names:
- cytokine synthesis inhibitory factor
- IL-10
- Il-10
Gene sequence:NCBI_Gene: 16153
Protein sequence:
Mouse Il10 target molecular function (prediction)
Acts upstream of or within several processes, including cellular response to hepatocyte growth factor stimulus; negative regulation of cytokine production; and response to bacterium. Located in extracellular space. Is expressed in colon; liver; thymus; and thymus primordium. Used to study inflammatory bowel disease. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Orthologous to human IL10 (interleukin 10).
Rat Il10 molecular target information
Molecular name: Il10, interleukin 10
Alias:
- CSIF
- cytokine synthesis inhibitory factor
- If2a
- IL-10
- IL10X
- interferon 2a
- interleukin-10
Gene sequence:NCBI_Gene: 25325
Protein sequence:
Rat Il10 target molecular function (prediction)
Enables interleukin-10 receptor binding activity. Involved in several processes, including cellular response to estradiol stimulus; liver regeneration; and negative regulation of nitric oxide biosynthetic process. Located in extracellular space. Used to study several diseases, including lung disease (multiple); perinatal necrotizing enterocolitis; sciatic neuropathy; toxic encephalopathy; and transient cerebral ischemia. Biomarker of several diseases, including artery disease (multiple); decubitus ulcer; lung disease (multiple); obstructive sleep apnea; and postpartum depression. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Orthologous to human IL10 (interleukin 10).