RETN molecular target information overview
Overview of RETN molecular targets
Resistin is a cysteine-rich, adipose-derived peptide hormone encoded by the RETN gene in humans. In primates, pigs, and dogs, resistin is secreted by immune and epithelial cells. In rodents, it is secreted by adipose tissue. The length of the human resistin propeptide is 108 amino acid residues, while that of mice and rats is 114 amino acid residues, with a molecular weight of approximately 12.5 kDa. Resistin accelerates the accumulation of low-density lipoprotein in the arteries, increasing the risk of heart disease. It can adversely affect the effects of statins, which are cholesterol-lowering drugs used to treat and prevent cardiovascular disease. Recent studies have found that resistin is also involved in inflammatory responses. Resistin does have the function of a pro-inflammatory cytokine and can serve as an important node in inflammatory diseases. Resistin is an adipose-derived hormone (similar to a cytokine), and its physiological role in obesity and type II diabetes has been a controversial topic.
Human RETN Molecular Target Information
Molecular name: RETN, resistin
Alias:
- adipose tissue-specific secretory factor
- ADSF
- C/EBP-epsilon regulated myeloid-specific secreted cysteine-rich protein precursor 1
- c/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein
- cysteine-rich secreted protein A12-alpha-like 2
- cysteine-rich secreted protein FIZZ3
- FIZZ3
- found in inflammatory zone 3
- MGC126603
- MGC126609
- resistin delta2
- RETN1
- RSTN
- XCP1
Gene sequence:NCBI_Gene: 56729
Protein sequence:UniProtKB: Q9HD89
Human RETN target molecular function (prediction)
Predicted to enable hormone activity. Predicted to be involved in several processes, including fat cell differentiation; negative regulation of feeding behavior; and positive regulation of cell communication. Located in extracellular exosome. Implicated in hypertension; hypertrophic cardiomyopathy; obesity; and type 2 diabetes mellitus. Biomarker of several diseases, including diabetes mellitus (multiple); diabetic neuropathy; heart disease (multiple); kidney failure (multiple); erythematosus.
Mouse Retn molecular target information
Molecular name: Retn, resistin
Alias:
- adipocyte-specific secretory factor
- ADSF
- Fizz3
- rstn
- Xcp4
Gene sequence:NCBI_Gene: 57264
Protein sequence:
Mouse Retn target molecular function (prediction)
Predicted to enable hormone activity. Predicted to be involved in several processes, including positive regulation of cell communication; positive regulation of smooth muscle cell migration; and positive regulation of smooth muscle cell proliferation. Located in extracellular space. Is expressed in adipose tissue; human RETN (resistin).
Rat Retn molecular target information
Molecular name: Retn, resistin
Alias:
- None
Gene sequence:NCBI_Gene: 246250
Protein sequence:
Rat Retn target molecular function (prediction)
Predicted to enable hormone activity. Involved in several processes, including positive regulation of cell communication; positive regulation of smooth muscle cell migration; and positive regulation of smooth muscle cell proliferation. Located in extracellular space and nucleus. Used to study colitis. Biomarker of non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in hypertension; hypertrophic cardiomyopathy; obesity; and type 2 diabetes mellitus. Orthologous to human RETN (resistin).