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IL15 molecular target information overview


  • Molecular name: IL15, interleukin 15
  • Gene family: Interleukins
  • Alias: IL-15; MGC9721


    • Overview of IL15 molecular targets


    Interleukin 15 (IL-15) is a proinflammatory protein that plays a role in the activation of neutrophils, dendritic cells, and macrophages and is essential for the development and survival of NK cells and CD8+ T cells. IL-15 activates the Jak/Stat pathway through heterotrimeric receptor signaling. Although IL-15 mRNA is expressed in many cell types, the secreted protein is rarely detected in biological samples. Recent studies have shown that IL-15 is retained intracellularly and can only be secreted extracellularly when it forms a complex with its sole receptor, IL-15Rα. Soluble IL-15/IL-15R complexes are produced by mouse dendritic cells, fibroblasts, and macrophages, and its binding activity is 10-100 times higher than that of IL-15 alone.


    Human IL15 molecular target information


    Molecular name: IL15, interleukin 15


    Alias:

    • IL-15
    • interleukin-15
    • MGC9721

    Gene sequence:NCBI_Gene: 3600

    Protein sequence:UniProtKB: P40933


    Human IL15 target molecular function (prediction)


    Predicted to enable cytokine activity. Involved in several processes, including cell surface receptor signaling pathway; macrophage differentiation; and positive regulation of macromolecule metabolic process. Located in cytosol and nuclear speck. Implicated in aspergillosis; asthma; pleurisy; and type 1 diabetes mellitus. Biomarker of several diseases, including artery disease (multiple); brain infarction; lung disease (multiple); obesity; and viral infectious disease (multiple).


    Mouse Il15 molecular target information


    Molecular name: Il15, interleukin 15


    Alias:

    • AI503618
    • expressed sequence AI503618


    Gene sequence:NCBI_Gene: 16168

    Protein sequence:


    Mouse Il15 target molecular function (prediction)


    Enables cytokine activity. Involved in negative regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including T cell activation; lymph node development; and regulation of lymphocyte activation. Located in cytoplasm. Is expressed in several structures, including adrenal gland; genitourinary system; gut; immune system; and nervous system. Orthologous to human IL15 (interleukin 15).


    Rat Il15 molecular target information


    Molecular name: Il15, interleukin 15

    Alias:

    • IL-15
    • interleukin-15

    Gene sequence:NCBI_Gene: 25670

    Protein sequence:UniProtKB: P97604


    Rat Il15 target molecular function (prediction)


    Predicted to enable cytokine activity. Involved in several processes, including cellular response to vitamin D; positive regulation of tyrosine phosphorylation of STAT protein; and skeletal muscle atrophy. Located in cell surface and extracellular space. Used to study pancreatitis. Biomarker of listeriosis and periodontal disease. Human ortholog(s) of this gene implicated in aspergillosis; asthma; pleurisy; and type 1 diabetes mellitus. Orthologous to human IL15 (interleukin 15).