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CCL17 molecular target information overview


  • Molecular name: CCL17, CC motif chemokine ligand 17
  • Gene family: Chemokine ligands
  • Alias: TARC; ABCD-2
  • Former name: SCYA17
  • Alias: small inducible cytokine subfamily A (Cys-Cys), member 17; chemokine (CC motif) ligand 17


    • CCL17 molecular target review


    Chemokine ligand (CCL17), also known as thymic activation-regulated chemokine (TARC), is a small molecular weight cytokine of the CC chemokine family. The CCL17 encoding gene is located on chromosome 16 in humans along with other chemokines CCL22 and CX3CL1. CCL17 is constitutively expressed in the thymus and transiently expressed in peripheral blood mononuclear cells stimulated by phytohemagglutinin (PHA). The chemokine specifically binds to T cells and exhibits its chemotactic effect by binding to the chemokine receptor CCR4.


    Human CCL17 Molecular Target Information


    Molecular name: CCL17, CC motif chemokine ligand 17


    Alias:

    • A-152E5.3
    • ABCD-2
    • CC motif chemokine 17
    • CC chemokine TARC
    • chemokine (CC motif) ligand 17
    • MGC138271
    • MGC138273
    • SCYA17
    • small inducible cytokine subfamily A (Cys-Cys), member 17
    • small-inducible cytokine A17
    • T cell-directed CC chemokine
    • TARC
    • thymus and activation-regulated chemokine

    Gene sequence:NCBI_Gene: 6361

    Protein sequence:UniProtKB: Q92583


    Human CCL17 target molecular function (prediction)


    Predicted to enable CCR chemokine receptor binding activity and chemokine activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide and killing of cells of other organism. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Biomarker of several diseases, including allergic bronchopulmonary aspergillosis; cystic fibrosis; lung disease (multiple); pulmonary eosinophilia; syncytial virus infectious disease.


    Mouse Ccl17 molecular target information


    Molecular name: Ccl17, chemokine (CC motif) ligand 17


    Alternate names:

    • ABCD-2
    • Scya17
    • small inducible cytokine subfamily A17
    • TARC


    Gene sequence:NCBI_Gene: 20295

    Protein sequence:


    Mouse Ccl17 target molecular function (prediction)


    Predicted to enable CCR4 chemokine receptor binding activity and chemokine activity. Acts upstream of or within negative regulation of myoblast differentiation. Predicted to be active in extracellular space. Is expressed in Sertoli cell; central nervous system; hemolymphoid system; and retina. Orthologous to human CCL17 (CC motif chemokine ligand 17).


    Rat Ccl17 molecular target information


    Molecular name: Ccl17, CC motif chemokine ligand 17

    Alias:

    • CC motif chemokine 17
    • chemokine (CC motif) ligand 17
    • Scya17
    • small inducible cytokine subfamily A (Cys-Cys), member 17
    • Tarc

    Gene sequence:NCBI_Gene: 117518

    Protein sequence:


    Rat Ccl17 target molecule function (prediction)


    Enables CCR4 chemokine receptor binding activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; leukocyte chemotaxis; and positive regulation of ERK1 and ERK2 cascade. Predicted to act upstream of or within negative regulation of myoblast differentiation. Predicted to be active in extracellular space. Biomarker of anti-basement membrane glomerulonephritis; asthma; pneumonia; and pulmonary fibrosis. Orthologous to human CCL17 (CC motif chemokine ligand 17).