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HAVCR2 molecular target information overview


  • Molecular name: HAVCR2, hepatitis A virus cellular receptor 2
  • Gene family: V-set domain containing
  • Alias: Tim-3; TIM3; FLJ14428; TIMD3; CD366
  • Alias: T-cell immunoglobulin mucin family member 3


    • HAVCR2 molecular target review


    CD366, also known as TIM-3, is a type I transmembrane glycoprotein that belongs to the TIM family within the immunoglobulin superfamily. CD366 is expressed on Th1, Th17, Treg, NK, NK-T, dendritic cells, monocytes, mast cells, and macrophages, but not on B cells and Th2 cells. CD366 regulates macrophage activation and is a negative regulator of Th1 cell function.


    Human HAVCR2 Molecular Target Information


    Molecular name:HAVCR2, hepatitis A virus cellular receptor 2


    Alias:

    • CD366
    • FLJ14428
    • HAVcr-2
    • kidney injury molecule-3
    • KIM-3
    • SPTCL
    • T cell immunoglobulin mucin 3
    • T cell immunoglobulin mucin-3
    • T-cell immunoglobulin and mucin domain-containing protein 3
    • T-cell immunoglobulin mucin family member 3
    • T-cell immunoglobulin mucin receptor 3
    • T-cell membrane protein 3
    • Tim-3
    • TIM3
    • TIMD-3
    • TIMD3

    Gene sequence:NCBI_Gene: 84868

    Protein sequence:UniProtKB: Q8TDQ0


    Human HAVCR2 target molecular function (prediction)


    Predicted to enable metal ion binding activity. Involved in several processes, including natural killer cell tolerance induction; negative regulation of leukocyte activation; and regulation of cytokine production. Located in cell surface. Implicated in hepatocellular carcinoma and renal cell carcinoma. Biomarker of cystic fibrosis and pulmonary tuberculosis.


    Mouse Havcr2 molecular target information


    Molecular name: Havcr2, hepatitis A virus cellular receptor 2


    Alias:

    • T-cell immunoglobulin and mucin domain containing 3
    • TIM-3
    • Tim3
    • Timd3


    Gene sequence:NCBI_Gene: 171285

    Protein sequence:


    Mouse Havcr2 target molecular function (prediction)


    Predicted to enable metal ion binding activity. Involved in several processes, including regulation of cytokine production; regulation of leukocyte activation; and toll-like receptor signaling pathway. Located in cell surface; early endosome; and immunological synapse. Is expressed in several structures, including dormal aorta; gut; liver; lung; and reproductive system. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and renal cell carcinoma. Orthologous to human HAVCR2 (hepatitis A virus cellular receptor 2).


    Rat Havcr2 molecular target information


    Molecular name: Havcr2, hepatitis A virus cellular receptor 2

    Alias:

    • HAVcr-2
    • hepatitis A virus cellular receptor 2 homolog
    • LOC363578
    • T cell immunoglobulin mucin-3
    • T-cell immunoglobulin and mucin domain-containing protein 3
    • T-cell immunoglobulin mucin receptor 3
    • T-cell membrane protein 3
    • TIM-3
    • tim3
    • TIMD-3

    Gene sequence:NCBI_Gene: 363578

    Protein sequence:UniProtKB: P0C0K5


    Rat Havcr2 target molecular function (prediction)


    Predicted to enable metal ion binding activity. Predicted to be involved in several processes, including regulation of cytokine production; regulation of leukocyte activation; and toll-like receptor signaling pathway. Located in cell surface. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and renal cell carcinoma. Orthologous to human HAVCR2 (hepatitis A virus cellular receptor 2).