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Overview of IL6 molecular targets

Interleukin 6 (IL-6) is a cytokine that has both pro-inflammatory and anti-inflammatory properties. In humans, it is encoded by the IL-6 gene. During infection and after trauma, especially inflammation caused by burns or other tissue damage, IL-6 is secreted by T cells and macrophages to promote immune responses. Studies have shown that IL-6 is required for mice to resist infection with Streptococcus pneumoniae, indicating that IL-6 plays a role in resisting infection. IL-6 can promote inflammatory and autoimmune disease processes in many diseases such as diabetes, atherosclerosis, depression, Alzheimer's disease, systemic lupus erythematosus, multiple myeloma, prostate cancer, Behcet's disease, and rheumatoid arthritis. Patients with advanced/metastatic cancer have higher levels of IL-6 in their blood.

Human IL6 Molecular Target Information

Molecular name: IL6, interleukin 6

Alias:

• B cell stimulatory factor-2
• B-cell differentiation factor
• B-cell stimulatory factor 2
• BSF-2
• BSF2
• CDF
• CTL differentiation factor
• HGF
• HSF
• hybridoma growth factor
• IFN-beta-2
• IFNB2
• IL-6
• interferon beta-2
• interferon, beta 2
• interleukin BSF-2
• interleukin-6

Gene sequence:NCBI_Gene: 3569

Protein sequence:UniProtKB: P05231

Human IL6 target molecular function (prediction)

Acts upstream of or within several processes, including cellular response to lipopolysaccharide; positive regulation of leukocyte adhesion to vascular endothelial cell; and positive regulation of macromolecule metabolic process. Located in extracellular space. Part of interleukin-6 receptor complex. Implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); glucose metabolism disease (multiple); and periodontal disease (multiple).

Mouse Il6 molecular target information

Molecular name: Il6, interleukin 6

Alias:

• Il-6

Gene sequence:NCBI_Gene: 16193

Protein sequence:

• UniprotKB: P08505
• UniprotKB: A0A0G2JFG1
• UniprotKB: A0A0G2JFT1
• UniprotKB: A0A0G2JGF4
• UniprotKB: A2RTD1
• UniprotKB: Q0PMN1
• UniprotKB: Q3U8J8

Mouse Il6 target molecular function (prediction)

Acts upstream of or within several processes, including cellular response to cytokine stimulus; regulation of gene expression; and salivary gland morphogenesis. Located in external side of plasma membrane and extracellular space. Part of interleukin-6 receptor complex. Is expressed in several structures, including adrenal gland; genitourinary system; gut; liver; and thymus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system cancer (multiple); glucose metabolism disease (multiple); and periodontal disease (multiple). Orthologous to human IL6 (interleukin 6).

Rat Il6 molecular target information

Molecular name: Il6, interleukin 6

Alias:

• Ifnb2
• IL-6
• ILg6
• Interleukin 6 (interferon beta 2)
• Interleukin 6 (interferon, beta 2)
• interleukin-6

Gene sequence:NCBI_Gene: 24498

Protein sequence:UniProtKB: P20607

Rat Il6 target molecular function (prediction)

Enables cytokine activity and interleukin-6 receptor binding activity. Involved in several processes, including cellular response to lipid; positive regulation of cell communication; and response to peptide hormone. Located in cytoplasm and extracellular space. Used to study several diseases, including acute necrotizing pancreatitis; disseminated intravascular coagulation; fatty liver disease; hypertension (multiple); and impotence. (multiple); auditory system disease (multiple); iron deficiency anemia; and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); glucose metabolism disease (multiple);