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CEACAM1 molecular target information overview


  • Molecular name:CEACAM1, CEA cell adhesion molecule 1
  • Gene family:CD molecules; V-set domain containing; CEA cell adhesion molecule family
  • Alias:BGP1;
  • Alias:carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein); carcinoembryonic antigen-related cell adhesion molecule 1


    • CEACAM1 molecular target review


    Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), also known as CD66a, is a member of the carcinoembryonic antigen (CEA) gene family in the immunoglobulin superfamily. The highly glycosylated CEACAM1 contains an N-terminal V-type Ig-like domain, three C2-type Ig-like domains, an ITIM motif, and a cytoplasmic calmodulin binding site. CEACAM1 is a surface glycoprotein expressed in a variety of blood cells, epithelial cells, and vascular cells. It is an adhesion molecule present in granulocytes, epithelial cells, and endothelial cells that mediates cell adhesion in a homophilic and heterophilic manner. Studies have shown that CEACAM1 plays a role in a variety of cellular processes including tissue differentiation, angiogenesis, apoptosis, metastasis, innate immunity, and regulation of adaptive immune responses.


    Human CEACAM1 Molecular Target Information


    Molecular name: CEACAM1, CEA cell adhesion molecule 1


    Alias:

    • antigen CD66
    • BGP
    • BGP-1
    • BGP1
    • BGPI
    • biliary glycoprotein 1
    • biliary glycoprotein adhesion molecule
    • carcinoembryonic antigen related cell adhesion molecule 1
    • carcinoembryonic antigen-related cell adhesion molecule 1
    • carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
    • CD66a antigen

    Gene sequence:NCBI_Gene: 634

    Protein sequence:UniProtKB: P13688


    Human CEACAM1 target molecular function (prediction)


    Enables cytoskeletal protein binding activity; enzyme binding activity; and identical protein binding activity. Involved in several processes, including negative regulation of T cell receptor signaling pathway; negative regulation of leukocyte mediated cytotoxicity; and wound healing, spreading of cells. Located in apical plasma membrane; cell surface; and cell-cell junction. Is integral component of membrane. Colocalizes with T cell receptor complex.


    Mouse Ceacam1 molecular target information


    Molecular name:Ceacam1, carcinoembryonic antigen-related cell adhesion molecule 1


    Alias:

    • Bgp
    • Bgp1
    • biliary glycoprotein
    • biliary glycoprotein 1
    • C-CAM
    • carcinoembryonic antigen 1
    • carcinoembryonic antigen 7
    • Cc1
    • CD66a
    • Cea-1
    • Cea-7
    • Cea1
    • Cea7
    • hepatitis virus (MHV-4) susceptibility
    • Hv-2
    • Hv2
    • mCEA1
    • Mhv-1
    • MHVR1
    • mmCGM1
    • mmCGM2
    • resistance to MHV (A59) replication in macrophages


    Gene sequence:NCBI_Gene: 26365

    Protein sequence:


    Mouse Ceacam1 target molecular function (prediction)


    Enables several functions, including signaling receptor binding activity; virion binding activity; and virus receptor activity. Involved in several processes, including common myeloid progenitor cell proliferation; granulocyte colony-stimulating factor signaling pathway; and negative regulation of macromolecule metabolic process. Acts upstream of or within several processes, including modulation by host of viral process; regulation of T cell activation; and regulation of intracellular signal transduction. Located in cell projection membrane; external side of plasma membrane; and extracellular space. structures, including alimentary system; central nervous system; extraembryonic component; genitourinary system; and skeleton. Orthologous to several human genes including CEACAM1 (CEA cell adhesion molecule 1).


    Rat Ceacam1 molecular target information


    Molecular name: Ceacam1, CEA cell adhesion molecule 1

    Alias:

    • adhesion molecule, CEA-like
    • adhesion molecule, CEA-like (mapped)
    • ATP-dependent taurocolate-carrier protein
    • Bgp
    • BGPR
    • C-CAM 105
    • carcinoembryonic antigen related cell adhesion molecule 1
    • carcinoembryonic antigen-related cell adhesion molecule
    • carcinoembryonic antigen-related cell adhesion molecule 1
    • carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
    • Ccam1
    • Ccam1_mapped
    • CD66a
    • CEA-related cell adhesion molecule 1
    • CEA-related cell adhesion molecule 1 (bone gamma-carboxyglutamic acid (Gla) protein) (osteocalcin)
    • cell-CAM 105
    • ecto-ATPase
    • GP110
    • osteocalcin
    • pp120
    • pp120/ecto-ATPase

    Gene sequence:NCBI_Gene: 81613

    Protein sequence:


    Rat Ceacam1 target molecular function (prediction)


    Enables several functions, including bile acid transmembrane transporter activity; calmodulin binding activity; and protein homodimerization activity. Involved in several processes, including homophilic cell adhesion via plasma membrane adhesion molecules; insulin catabolic process; and regulation of signal transduction. Acts upstream of or within positive regulation of MAP kinase activity. Located in several cellular components, including adherens junction; basal plasma membrane; CEACAM1 (CEA cell adhesion molecule 1).