Blog

PDGFRB molecular target information overview


  • Molecular name: PDGFRB, platelet derived growth factor receptor beta
  • Gene family: Receptor tyrosine kinases; CD molecules; I-set domain containing
  • Alias: JTK12;
  • Alias: platelet-derived growth factor receptor, beta polypeptide


    • Overview of PDGFRB molecular targets


    Platelet-derived growth factor receptor β (PDGFRB), also known as CD140b, and the structural homologous protein PDGFRA (CD140a) are members of the class III subfamily of receptor tyrosine kinases (RTKs), which also includes receptors for M-CSF, SCF, and Flt-3 ligand. All class III RTKs contain five immunoglobulin-like domains in the extracellular region and a kinase domain in the intracellular region. PDGF is an important serum mitogen that can form homo- or heterodimeric proteins by linking the PDGF-A chain and PDGF-B chain through disulfide bonds. PDGFRA and PDGFRB bind to PDGF-AA, PDGF-BB, and PDGF-AB isomers with different affinities, with PDGFRA binding to all three PDGF isomers with high affinity, while PDGFRB can only bind to PDGF-BB with high affinity. PDGF binding can induce receptor homo- and heterodimerization and signal transduction. PDGFRA and PDGFRB are independently regulated in a variety of cell types. Recombinant soluble PDGFRB binds PDGF with high affinity and is a potent PDGF antagonist.


    Human PDGFRB molecular target information


    Molecular name: PDGFRB, platelet derived growth factor receptor beta


    Alias:

    • Activated tyrosine kinase PDGFRB
    • beta-type platelet-derived growth factor receptor
    • CD140 antigen-like family member B
    • CD140B
    • IBGC4
    • IMF1
    • JTK12
    • KOGS
    • NDEL1-PDGFRB
    • PDGF-R-beta
    • PDGFR
    • PDGFR-1
    • PDGFR-beta
    • PDGFR1
    • PENTT
    • platelet-derived growth factor receptor 1
    • platelet-derived growth factor receptor beta
    • platelet-derived growth factor receptor, beta polypeptide

    Gene sequence:NCBI_Gene: 5159

    Protein sequence:UniProtKB: P09619


    Human PDGFRB target molecular function (prediction)


    Enables several functions, including growth factor binding activity; platelet-derived growth factor beta-receptor activity; and platelet-derived growth factor receptor binding activity. Involved in several processes, including platelet-derived growth factor receptor signaling pathway; positive regulation of phosphate metabolic process; and protein phosphorylation. Located in Golgi apparatus and membrane. myeloproliferative neoplasm (multiple); and renal cell carcinoma. Biomarker of Kuhnt-Junius degeneration; breast cancer (multiple); renal cell carcinoma; and reproductive organ cancer (multiple).


    Mouse Pdgfrb molecular target information


    Molecular name:Pdgfrb, platelet derived growth factor receptor, beta polypeptide


    Alternate names:

    • AI528809
    • CD140b
    • expressed sequence AI528809
    • Pdgfr
    • platelet derived growth factor receptor


    Gene sequence:NCBI_Gene: 18596

    Protein sequence:


    Mouse Pdgfrb target molecular function (prediction)


    Acts upstream of or within several processes, including animal organ development; response to ceramide; and ruffle assembly. Located in cell surface; cytoplasm; and ruffle. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Used to study basal ganglia calcification; infantile myofibromatosis; myeloproliferative neoplasm; and severe nonproliferative diabetic retinopathy. Human ortholog(s) of this gene implicated in basal ganglia calcification; human PDGFRB (platelet derived growth factor receptor beta).


    Rat Pdgfrb molecular target information


    Molecular name: Pdgfrb, platelet derived growth factor receptor beta

    Alias:

    • beta platelet-derived growth factor receptor
    • beta-type platelet-derived growth factor receptor
    • CD140 antigen-like family member B
    • PDGF-R-beta
    • PDGFR-1
    • PDGFR-beta
    • platelet derived growth factor receptor, beta polypeptide
    • platelet-derived growth factor receptor 1
    • Platelet-derived growth factor receptor beta
    • platelet-derived growth factor receptor beta variant 1
    • Platelet-derived growth factor receptor, beta

    Gene sequence:NCBI_Gene: 24629

    Protein sequence: UniProtKB: Q05030


    Rat Pdgfrb target molecular function (prediction)


    Enables phosphatidylinositol 3-kinase binding activity and platelet-derived growth factor-activated receptor activity. Involved in several processes, including animal organ development; positive regulation of Rho protein signal transduction; and regulation of apoptotic process. Located in several cellular components, including apical plasma membrane; cell surface; and nucleus. Used to study extrahepatic cholestasis; middle cerebral artery infarction; and prostate cancer. Biomarker of hypertension; oligohydramnios; and sciatic neuropathy. Human ortholog(s) of this gene implicated in basal ganglia calcification; glioblastoma; infantile myofibromatosis; myeloproliferative neoplasm (multiple); and renal cell carcinoma. Orthologous to human PDGFRB (platelet derived growth factor receptor beta).