Overview of CTSD molecular target information
Overview of CTSD molecular targets
Cathepsin D is a protein encoded by the CTSD gene. Cathepsin D is a lysosomal aspartyl protease that is activated at low pH. It is widely found in vertebrates, fungi, retroviruses, and some plant viruses. Normally, cathepsin D is first synthesized in the rough endoplasmic reticulum as a catalytically inactive proenzyme, which enters the Golgi apparatus for protein cleavage and processing after removal of the signal peptide, and finally enters the lysosome via the mannose-6-phosphate pathway. In mammals, the active mature protein form contains 1 light chain and 1 heavy chain. Cathepsin D is widely expressed and participates in proteolytic degradation, cell invasion, and apoptosis. Mutations in the cathepsin D gene have been implicated in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer's disease, and have been considered a tumor marker for breast cancer.
Human CTSD Molecular Target Information
Molecule name: CTSD, cathepsin D
Alias:
- cathepsin d (lysosomal aspartyl protease)
- ceroid-lipofuscinosis, neuronal 10
- CLN10
- CPSD
- epididymis secretory sperm binding protein Li 130P
- HEL-S-130P
- lysosomal aspartyl peptidase
- lysosomal aspartyl protease
- MGC2311
Gene sequence:NCBI_Gene: 1509
Protein sequence:UniProtKB: P07339
Human CTSD target molecular function (prediction)
Enables peptidase activity. Involved in several processes, including lipoprotein catabolic process; positive regulation of apoptotic process; and positive regulation of cysteine-type endopeptidase activity involved in apoptotic process. Located in endosome membrane; lysosomal membrane; and membrane raft. Colocalizes with collagen-containing extracellular matrix. Implicated in Alzheimer's disease; breast cancer; and neuronal ceroid lipofuscinosis 10. Biomarker of Alzheimer's disease.
Mouse Ctsd molecular target information
Molecule name: Ctsd, cathepsin D
Alias:
- CatD
- CD
Gene sequence:NCBI_Gene: 13033
Protein sequence:
- UniprotKB: P18242
- UniprotKB: F8WIR1
- UniprotKB: Q05BF3
- UniprotKB: Q3TIR0
- UniprotKB: Q3TJN3
- UniprotKB: Q3TWD0
- UniprotKB: Q3TWL1
- UniprotKB: Q3TWR6
- UniprotKB: Q3TXL5
- UniprotKB: Q3U651
- UniprotKB: Q3U7I9
- UniprotKB: Q3U7P0
- UniprotKB: Q3U8W5
- UniprotKB: Q3UAQ1
- UniprotKB: Q3UC89
- UniprotKB: Q3UCD9
- UniprotKB: Q3UCW4
Mouse Ctsd target molecular function (prediction)
Enables aspartic-type endopeptidase activity. Acts upstream of or within autophagosome assembly. Located in extracellular space and lysosome. Is expressed in several structures, including central nervous system; extraembryonic component; eye; genitourinary system; and optic nerve. Used to study neuronal ceroid lipofuscinosis 10. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; lipofuscinosis 10. Orthologous to human CTSD (cathepsin D).
Rat Ctsd molecular target information
Molecule name: Ctsd, cathepsin D
Alias:
- None
Gene sequence:NCBI_Gene: 171293
Protein sequence:
Rat Ctsd target molecular function (prediction)
Enables endopeptidase activity and peptide binding activity. Involved in proteolysis and response to nutrient levels. Located in lysosome. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; and neuronal ceroid lipofuscinosis 10. Orthologous to human CTSD (cathepsin D).