TNFSF14 molecular target information overview
Overview of TNFSF14 molecular targets
CD258, also known as LIGHT and tumor necrosis factor superfamily member 14 (TNFSF14), is a secreted protein belonging to the TNF superfamily. It is a type II transmembrane protein expressed on activated T cells and immature dendritic cells, recognized by herpes virus entry mediator (HVEM) and decoy receptor 3. This protein can act as a co-stimulatory factor for lymphocyte activation and an inhibitor of herpes virus infection, which can stimulate T cell proliferation, cause apoptosis of various tumor cells and prevent viral invasion. It has also been reported to prevent TNF α-mediated apoptosis in primary hepatocytes. In addition, CD258 is also involved in the development and homeostasis of T cells, the maturation of dendritic cells and atherosclerosis, and plays a significant role in diseases involving T cells such as graft-versus-host disease (GVHD) and autoimmune diseases.
Human TNFSF14 Molecular Target Information
Molecular name: TNFSF14, TNF superfamily member 14
Alias:
- CD258
- delta transmembrane LIGHT
- herpes virus entry mediator ligand
- herpesvirus entry mediator A
- herpesvirus entry mediator ligand
- herpesvirus entry mediator-ligand
- HVEML
- ligand for herpesvirus entry mediator
- LIGHT
- LTg
- TNLG1D
- TR2
- tumor necrosis factor (ligand) superfamily member 14
- tumor necrosis factor (ligand) superfamily, member 14
- tumor necrosis factor ligand 1D
- tumor necrosis factor ligand superfamily member 14
- tumor necrosis factor receptor-like 2
- tumor necrosis factor superfamily member 14
- tumor necrosis factor superfamily member LIGHT
Gene sequence:NCBI_Gene: 8740
Protein sequence:UniProtKB: O43557
Human TNFSF14 target molecular function (prediction)
Enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process; identical protein binding activity; and signaling receptor binding activity. Involved in T cell costimulation; cellular response to mechanical stimulus; and positive regulation of NIK/NF-kappaB signaling. Predicted to be located in plasma membrane.
Mouse Tnfsf14 molecular target information
Molecular name:Tnfsf14, tumor necrosis factor (ligand) superfamily, member 14
Alias:
- HVEM-L
- LIGHT
Gene sequence:NCBI_Gene: 50930
Protein sequence:
Mouse Tnfsf14 target molecular function (prediction)
Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process; identical protein binding activity; and signaling receptor binding activity. Acts upstream of or within several processes, including T cell costimulation; positive regulation of T cell chemotaxis; and positive regulation of myoblast fusion. Predicted to be located in plasma membrane. Used to study IgA glomerulonephritis. Orthologous to human TNFSF14 (TNF superfamily member 14).
Rat Tnfsf14 molecular target information
Molecular name: Tnfsf14, TNF superfamily member 14
Synonyms:
- LOC301133
- similar to Tumor necrosis factor ligand superfamily member 14 (CD258 antigen)
- Tnlg1d
- tumor necrosis factor (ligand) superfamily, member 14
- tumor necrosis factor ligand 1d
- tumor necrosis factor ligand superfamily member 14
- tumor necrosis factor superfamily member 14
Gene sequence:NCBI_Gene: 301133
Protein sequence:UniProtKB: M0RCN2
Rat Tnfsf14 target molecular function (prediction)
Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process; identical protein binding activity; and signaling receptor binding activity. Predicted to be involved in cellular response to mechanical stimulus and positive regulation of NIK/NF-kappaB signaling. Predicted to act upstream of or within several processes, including T cell costimulation; positive regulation of T cell chemotaxis; and positive regulation of myoblast fusion. Predicted to be integral component of membrane. Orthologous to human TNFSF14 (TNF superfamily member 14).