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PDGFB molecular target information overview


  • Molecular name: PDGFB, platelet derived growth factor subunit B
  • Alias: SSV
  • Previous name: SIS
  • Alias: oncogene SIS; becaplermin; platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog); platelet-derived growth factor beta polypeptide


    • Overview of PDGFB molecular targets


    Platelet-derived factor (PDGF) is one of many factors that regulate cell growth and division. Chemically, PDGF is a dimeric glycoprotein formed by two A chains (-AA) or two B chains (-BB) or a combination of AB chains (-AB). In particular, it plays an important role in angiogenesis, the growth of existing vascular tissue. Uncontrolled angiogenesis is a characteristic of tumors. Hepatocytes and non-resorbing osteoclasts express PDGF-BB, which produces osteoblasts and bone, and platelets, macrophages, and mast cells can also produce PDGF-BB. At the site of injury, PDGF-BB promotes the infiltration of neutrophils and macrophages, plays a debridement role, promotes fibroblasts to secrete new extracellular matrix, and promotes IGF-1-mediated re-epithelialization.


    Human PDGFB Molecular Target Information


    Molecular name:PDGFB, platelet derived growth factor subunit B


    Alias:

    • becaplermin
    • c-sis
    • FLJ12858
    • IBGC5
    • PDGF subunit B
    • PDGF-2
    • PDGF, B chain
    • PDGF2
    • platelet-derived growth factor 2
    • platelet-derived growth factor B chain
    • platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
    • platelet-derived growth factor subunit B
    • platelet-derived growth factor, B chain
    • Platelet-derived growth factor, beta polypeptide (oncogene SIS)
    • proto-oncogene c-Sis
    • SIS
    • SSV

    Gene sequence:NCBI_Gene: 5155

    Protein sequence: UniProtKB: P01127


    Human PDGFB target molecular function (prediction)


    Enables several functions, including platelet-derived growth factor binding activity; protein dimerization activity; and receptor ligand activity. Involved in several processes, including positive regulation of cell migration; positive regulation of cell population proliferation; and positive regulation of phosphorylation. Located in cell surface. Implicated in basal ganglia calcification; clear cell renal cell carcinoma; connective tissue cancer (multiple); familial meningioma; Kuhnt-Junius degeneration; bone disease (multiple); clear cell renal cell carcinoma; diabetic retinopathy (multiple); and reproductive organ cancer (multiple).


    Mouse Pdgfb molecular target information


    Molecular name: Pdgfb, platelet derived growth factor, B polypeptide


    Alternate names:

    • PDGF-B
    • simian sarcoma oncogene
    • Sis


    Gene sequence:NCBI_Gene: 18591

    Protein sequence:


    Mouse Pdgfb target molecular function (prediction)


    Predicted to enable several functions, including platelet-derived growth factor binding activity; protein dimerization activity; and receptor ligand activity. Involved in several processes, including metanephric glomerular mesangium development; paracrine signaling; and positive regulation of glomerular filtration. Acts upstream of or within several processes, including animal organ development; nervous system development; and regulation of cell migration. Predicted to be located in several cellular components, including basolateral plasma membrane; dendrite; and neuronal cell body. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; cardiovascular system; extraembryonic component; female reproductive system; and nervous system. Human ortholog(s) of this gene implicated in basal ganglia calcification; clear cell renal cell carcinoma; connective tissue cancer (multiple); familial meningioma; and prostatic hypertrophy. Orthologous to human PDGFB (platelet derived growth factor subunit B).


    Rat Pdgfb molecular target information


    Molecular name:Pdgfb, platelet derived growth factor subunit B

    Alias:

    • c-sis
    • pdgf protein
    • PDGF subunit B
    • PDGF-2
    • platelet derived growth factor-bb
    • platelet derived growth factor, B polypeptide
    • Platelet-derived growth factor
    • platelet-derived growth factor B chain
    • platelet-derived growth factor beta polypeptide
    • platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
    • Platelet-derived growth factor same as Sis (Simian sarcoma viral oncogene homologue c-sis)
    • platelet-derived growth factor subunit B
    • Platelet-derived growth factor, same as Sis (Simian sarcoma viral oncogene homologue, c-sis)
    • SIS

    Gene sequence:NCBI_Gene: 24628

    Protein sequence:


    Rat Pdgfb target molecular function (prediction)


    Enables signaling receptor binding activity. Involved in several processes, including positive regulation of biosynthetic process; positive regulation of cell migration; and response to peptide hormone. Located in several cellular components, including basolateral plasma membrane; dendrite; and neuronal cell body. Used to study asthma; brain infarction; glomerulonephritis; and visual epilepsy. Biomarker of cholestasis; hypertension (multiple); liver cirrhosis; oligohydramnios; and ureteral obstruction. Human ortholog(s) of this gene implicated in basal ganglia calcification; clear cell renal cell carcinoma; connective tissue cancer (multiple); familial meningioma; and prostatic hypertrophy. Orthologous to human PDGFB (platelet derived growth factor subunit B).