BCL2 molecular target information overview
BCL2 molecular target review
B-cell lymphoma 2 (Bcl-2), a founding member of the Bcl-2 family of regulatory proteins, regulates apoptosis by either inducing apoptosis (pro-apoptotic) or inhibiting apoptosis (anti-apoptotic). Bcl-2 has been identified as an important anti-apoptotic protein and is therefore classified as an oncogene. Bcl-2 regulates mitochondrial dynamics and is involved in the regulation of mitochondrial fusion and fission. In addition, in pancreatic beta cells, Bcl-2 and Bcl-XL are involved in controlling metabolic activity and insulin secretion. Damage to the Bcl-2 gene can cause many cancers, including melanoma, breast cancer, prostate cancer, chronic lymphocytic leukemia, and lung cancer, and may also be associated with schizophrenia and autoimmune diseases. Bcl-2 is also a cause of resistance to cancer treatment.
Human BCL2 Molecular Target Information
Molecular name: BCL2, BCL2 apoptosis regulator
Alias:
- apoptosis regulator Bcl-2
- B-cell CLL/lymphoma 2
- b-cell leukemia/lymphoma 2
- Bcl-2
- Bcl-2a
- Bcl-2?
- BCL2, apoptosis regulator
- PPP1R50
- protein phosphatase 1, regulatory subunit 50
Gene sequence:NCBI_Gene: 596
Protein sequence: UniProtKB: P10415
Human BCL2 target molecular function (prediction)
Acts upstream of or within several processes, including B cell proliferation; apoptotic signaling pathway; and negative regulation of apoptotic process. Located in endoplasmic reticulum; mitochondrial outer membrane; and nucleus. Part of pore complex. Implicated in several diseases, including carcinoma (multiple); hematologic cancer (multiple); intracranial aneurysm; prostate cancer; and urinary bladder cancer.
Mouse Bcl2 molecular target information
Molecular Name: Bcl2, B cell leukemia/lymphoma 2
Alias:
- AW986256
- Bcl-2
- C430015F12Rik
- D630044D05Rik
- D830018M01Rik
- expressed sequence AW986256
- RIKEN cDNA C430015F12 gene
- RIKEN cDNA D630044D05 gene
- RIKEN cDNA D830018M01 gene
Gene sequence:NCBI_Gene: 12043
Protein sequence:
Mouse Bcl2 target molecular function (prediction)
Acts upstream of or within several processes, including animal organ development; apoptotic signaling pathway; and negative regulation of programmed cell death. Located in several cellular components, including mitochondrial membrane; myelin sheath; and nuclear membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut; limb; and sensory organ. Used to study oligomeganephronia. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; carcinoma (multiple); hematologic cancer (multiple); intracranial aneurysm; and prostate cancer. Orthologous to human BCL2 (BCL2 apoptosis regulator).
Rat Bcl2 molecular target information
Molecular name: Bcl2, BCL2, apoptosis regulator
Alias:
- apoptosis regulator Bcl-2
- B cell lymphoma 2 associated oncogene
- B-cell CLL/lymphoma 2
- B-cell leukemia/lymphoma 2
- Bcl-2
- Bcl-2alpha
- Bcl2-like protein
Gene sequence:NCBI_Gene: 24224
Protein sequence:
Rat Bcl2 target molecule function (prediction)
Enables BH domain binding activity. Involved in several processes, including response to peptide; response to purine-containing compound; and response to vitamin. Located in cytosol; mitochondrial crista; and perinuclear region of cytoplasm. Used to study several diseases, including brain ischemia (multiple); end stage renal disease; gastric ulcer; intestinal disease (multiple); and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); hematologic cancer (multiple); intracranial aneurysm; prostate cancer; and urinary bladder cancer. Orthologous to human BCL2 (BCL2 apoptosis regulator).