ARG1 molecular target information overview
ARG1 molecular target review
Arginase is a key element of the urea cycle, catalyzing the conversion of L-arginine to urea and L-ornithine, which in turn promote collagen synthesis and cell proliferation. Arginine metabolism is a key regulator of innate and adaptive immune responses and is involved in the antimicrobial effector pathway of polymorphonuclear granulocytes (PMNs). During PMN apoptosis, arginine is depleted in the microenvironment, which inhibits the proliferation of T cells and natural killer cells and the secretion of cytokines. Arginase 1 (ARG1) is a member of the arginase family with a molecular weight of 35-40 kDa. It is expressed in many cell types, including erythrocytes, hepatocytes, neutrophils, smooth muscle, and macrophages. Human AGR1 is 322 amino acids (aa) in length. Its enzymatic region consists of amino acids 9-309 and contains two Mn atoms. ARG1 monomers have moderate activity, but as homotrimers of 105 kDa, it is highly active.
Human ARG1 Molecular Target Information
Molecular name: ARG1, arginase 1
Alias:
- arginase-1
- arginase, liver
- liver-type arginase
- type I arginase
Gene sequence:NCBI_Gene: 383
Protein sequence:UniProtKB: P05089
Human ARG1 target molecular function (prediction)
Predicted to enable arginase activity and manganese ion binding activity. Involved in negative regulation of T cell proliferation; negative regulation of interferon-gamma-mediated signaling pathway; and positive regulation of neutrophil mediated killing of fungus. Located in extracellular space. Implicated in asthma; hepatocellular carcinoma; and hyperargininemia. Biomarker of asthma and colitis.
Mouse Arg1 molecular target information
Molecular Name: Arg1, arginase, liver
Alias:
- AI
- AI256583
- Arg-1
- expressed sequence AI256583
- PGIF
Gene sequence:NCBI_Gene: 11846
Protein sequence:
Mouse Arg1 target molecular function (prediction)
Enables arginase activity. Involved in defense response to protozoan; negative regulation of T-helper 2 cell cytokine production; and negative regulation of activated T cell proliferation. Predicted to be located in several cellular components, including extracellular space; mitochondrial outer membrane; and neuronal cell body. Predicted to be active in cytosol. Used to study hyperargininemia. Human ortholog(s) of this gene implicated in asthma; hepatocellular carcinoma; and hyperargininemia. Orthologous to human ARG1 (arginase 1).
Rat Arg1 molecular target information
Molecular name: Arg1, arginase 1
Alias:
- AI type I arginase
- AI, type I arginase
- arginase 1 liver
- Arginase 1, liver
- arginase-1
- arginase, liver
- liver-type arginase
- type I arginase
Gene sequence:NCBI_Gene: 29221
Protein sequence:UniProtKB: P07824
Rat Arg1 target molecular function (prediction)
Enables arginase activity; identical protein binding activity; and manganese ion binding activity. Involved in several processes, including cellular response to hormone stimulus; gland development; and response to vitamin. Located in several cellular components, including extracellular space; mitochondrial outer membrane; and neuronal cell body. Used to study acute necrotizing pancreatitis and hypertension. Biomarker of several diseases, including acute kidney failure; cholestasis; silicosis; ureteral obstruction; and uveitis. Human Ortholog(s) of this gene implicated in asthma; hepatocellular carcinoma; and hyperargininemia. Orthologous to human ARG1 (arginase 1).