VCAM1 molecular target information overview
VCAM1 molecular targets review
Vascular cell adhesion molecule 1 (VCAM-1), also known as CD106, is a 100-110 kDa type I transmembrane protein that typically has seven C2-type immunoglobulin domains and functions as a cell adhesion molecule. The VCAM-1 protein mediates the adhesion of lymphocytes, monocytes, eosinophils, and basophils to the vascular endothelium. VCAM-1 is the endothelial ligand for integrin β1 subfamily VLA-4 (very late antigen-4 or α4β1) and integrin α4β7. VCAM-1 expression has also been observed on other cell types. It can also interact with EZR and moesin. Other functions of VCAM-1 include regulation of osteoclastogenesis through cell-cell contacts and induction of sickle cell adhesion to vascular endothelial cells in response to hypoxia. It also plays a role in leukocyte-endothelial cell signaling. Monitoring sVCAM-1 expression levels in serum can provide a more detailed perspective on a variety of pathological conditions, such as atherosclerosis and rheumatoid arthritis.
Human VCAM1 Molecular Target Information
Molecular name: VCAM1, vascular cell adhesion molecule 1
Alias:
- CD106
- CD106 antigen
- DKFZp779G2333
- INCAM-100
- MGC99561
- vascular cell adhesion protein 1
Gene sequence:NCBI_Gene: 7412
Protein sequence:UniProtKB: P19320
Human VCAM1 target molecular function (prediction)
Enables integrin binding activity and primary amine oxidase activity. Involved in several processes, including calcium-mediated signaling using intracellular calcium source; cell-cell adhesion in response to extracellular stimulus; and cellular response to amyloid-beta. Located in several cellular components, including early endosome; external side of plasma membrane; and podosome. Part of alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex. Biomarker of several diseases, including artery disease (multiple); diabetes mellitus (multiple); essential thrombocythemia; glomerulonephritis (multiple); and interstitial cystitis.
Mouse Vcam1 molecular target information
Molecular name: Vcam1, vascular cell adhesion molecule 1
Alias:
- CD106
- Vcam-1
Gene sequence:NCBI_Gene: 22329
Protein sequence:
- UniprotKB: P29533
- UniprotKB: A0A0G2JFP9
- UniprotKB: Q3TR98
- UniprotKB: Q3UPN1
- UniprotKB: Q8K0X1
- UniprotKB: Q91X98
Mouse Vcam1 target molecular function (prediction)
Predicted to enable integrin binding activity and primary amine oxidase activity. Acts upstream of or within several processes, including cellular response to glucose stimulus; chorio-allantoic fusion; and heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Located in apical plasma membrane. Is expressed in several structures, including brain; embryo mesenchyme; extraembryonic component; heart; and hemolymphoid system. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human VCAM1 (vascular cell adhesion molecule 1).
Rat Vcam1 molecular target information
Molecular name: Vcam1, vascular cell adhesion molecule 1
Alias:
- LOC100912479
- MGC108734
- V-CAM 1
- vascular cell adhesion protein 1
- vascular cell adhesion protein 1-like
- VCAM-1
- VCAM1B
Gene sequence:NCBI_Gene: 25361
Protein sequence:
Rat Vcam1 target molecular function (prediction)
Enables integrin binding activity. Involved in several processes, including cellular response to tumor necrosis factor; nervous system development; and response to lipopolysaccharide. Located in cell surface; extracellular space; and sarcolemma. Used to study carotid stenosis and hypertension. Biomarker of several diseases, including artery disease (multiple); chronic kidney disease; colitis; periodontitis; and thromboangiitis obliterans. Orthologous to human VCAM1 (vascular cell adhesion molecule 1).