Blog

SFTPD molecular target information overview


  • Molecular name: SFTPD, surfactant protein D
  • Gene family: Collectins; C-type lectin domain containing
  • Other names: SP-D; COLEC7
  • Former name: SFTP4
  • Alias: surfactant, pulmonary-associated protein D


    • Overview of SFTPD molecular targets


    Surfactant protein D (SP-D) has a molecular weight of 43kDa and is a member of the collagen lectin family with innate immune regulatory effects. It is constitutively secreted by alveolar lining cells and epithelial cells associated with tubular structures, and is induced in cardiac smooth muscle and endothelial cells. Human SP-D is present in serum, plasma, bronchoalveolar lavage fluid, and amniotic fluid. SP-D plays an important role in body defense and innate immunity. SP-D binds to neutrophil defensins and regulates antiviral defense. Current studies have shown that SP-D is involved in the occurrence and development of a variety of lung diseases and can serve as a biomarker for these diseases.


    Human SFTPD Molecular Target Information


    Molecular Name: SFTPD, surfactant protein D


    Alias:

    • COLEC7
    • collectin 7
    • collectin-7
    • lung surfactant protein D
    • PSP-D
    • pulmonary surfactant apoprotein
    • pulmonary surfactant-associated protein D
    • SFTP4
    • SP-D
    • surfactant-associated protein, pulmonary 4
    • surfactant, pulmonary-associated protein D

    Gene sequence:NCBI_Gene: 6441

    Protein sequence:UniProtKB: P35247


    Human SFTPD target molecular function (prediction)


    Predicted to enable identical protein binding activity. Involved in several processes, including induction of bacterial agglutination; negative regulation by host of symbiont catalytic activity; and surfactant homeostasis. Predicted to be located in cytoplasm. Predicted to be part of collagen trimer. Predicted to be active in extracellular space; syncytial virus infectious disease; and rhinitis. Biomarker of several diseases, including cystic fibrosis; lung disease (multiple); respiratory syncytial virus infectious disease; sarcoidosis; and systemic lupus erythematosus.


    Mouse Sftpd molecular target information


    Molecular name: Sftpd, surfactant associated protein D


    Alias:

    • AI573415
    • expressed sequence AI573415
    • Sfpd
    • Sftp4
    • SP-D
    • surfactant-associated protein 4


    Gene sequence:NCBI_Gene: 20390

    Protein sequence:


    Mouse Sftpd target molecular function (prediction)


    Enables identical protein binding activity. Predicted to be involved in several processes, including induction of bacterial agglutination; negative regulation of interleukin-2 production; and regulation of phagocytosis. Predicted to act upstream of or within innate immune response and respiratory gaseous exchange by respiratory system. Located in cytoplasm. syncytial virus infectious disease; and rhinitis. Orthologous to human SFTPD (surfactant protein D).


    Rat Sftpd molecular target information


    Molecular Name: Sftpd, surfactant protein D

    Alias:

    • CP4
    • lung surfactant protein D
    • PSP-D
    • pulmonary surfactant protein D
    • pulmonary surfactant-associated protein D
    • SP-D
    • SPD
    • surfactant associated protein D
    • surfactant pulmonary-associated protein D
    • surfactant, pulmonary-associated protein D

    Gene sequence:NCBI_Gene: 25350

    Protein sequence: