Overview of LIF molecular target information
Overview of LIF molecular targets
Leukemia inhibitory factor (LIF) is a cytokine of the interleukin 6 family that affects cell growth by inhibiting differentiation. When LIF levels decrease, cells differentiate. Activated T cells, monocytes, astrocytes, osteoblasts, keratinocytes, mast cells, and fibroblasts can express LIF. LIF is named because it can induce terminal differentiation of myeloid leukemia cells and prevent the continued growth of leukemia cells. Other properties of LIF include promoting growth, promoting differentiation of different types of target cells, affecting bone metabolism, cachexia, neurodevelopment, embryonic development, and inflammation. LIF is involved in the process of endometrial decidualization and embryo implantation in the endometrium during pregnancy. When LIF and other cytokine levels in women decrease, they are more likely to become pregnant, but the risk of unexplained recurrent miscarriage increases. Studies have shown that recombinant human LIF may help improve implantation rates in women with unexplained infertility. In addition, LIF is often added to stem cell culture media to reduce spontaneous differentiation.
Human LIF molecular target information
Molecular name:LIF, LIF interleukin 6 family cytokine
Alias:
- CDF
- cholinergic differentiation factor
- D factor
- DIA
- differentiation inhibitory activity
- differentiation stimulating factor
- differentiation-inducing factor
- differentiation-stimulating factor
- hepatocyte-stimulating factor III
- HILDA
- human interleukin in DA cells
- leukemia inhibitory factor
- LIF, interleukin 6 family cytokine
- melanoma-derived LPL inhibitor
- MLPLI
Gene sequence:NCBI_Gene: 3976
Protein sequence:UniProtKB: P15018
Human LIF target molecular function (prediction)
Acts upstream of or within several processes, including positive regulation of MAPK cascade; positive regulation of macrophage differentiation; and positive regulation of protein phosphorylation. Located in cytosol.
Mouse Lif molecular target information
Molecular name: Lif, leukemia inhibitory factor
Alias:
- None
Gene sequence:NCBI_Gene: 16878
Protein sequence:
Mouse Lif target molecular function (prediction)
Enables cytokine activity and growth factor activity. Acts upstream of or within several processes, including animal organ development; generation of neurons; and positive regulation of macromolecule metabolic process. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; cranium; early conceptus; and female reproductive system. Orthologous to human LIF (LIF interleukin 6 family cytokine).
Rat Lif molecular target information
Molecular name:Lif, LIF, interleukin 6 family cytokine
Alias:
- cholinergic neuronal differentiation factor
- leukemia inhibitory factor
- leukemia inhibitory factor (cholinergic differentiation factor)
Gene sequence:NCBI_Gene: 60584
Protein sequence:
Rat Lif target molecular function (prediction)
Enables leukemia inhibitory factor receptor binding activity. Involved in several processes, including negative regulation of angiogenesis; positive regulation of corticotropin secretion; and transdifferentiation. Located in extracellular space. Biomarker of brain ischemia and congestive heart failure. Orthologous to human LIF (LIF interleukin 6 family cytokine).