CCL11 molecular target information overview
CCL11 molecular target review
Chemokine ligand 11 (CCL11), also known as eotaxin, is a small molecular weight cytokine in the CC chemokine family. Eotaxin is involved in allergic reactions by inducing chemotaxis for the selective recruitment of eosinophils. Elevated expression of Eotaxin in human and mouse plasma is associated with aging. Current cannabis users have higher plasma levels of Eotaxin compared to former and never cannabis users. Eotaxin concentrations are also higher in schizophrenia patients, and cannabis is a known inducer of schizophrenia.
Human CCL11 Molecular Target Information
Molecular name: CCL11, CC motif chemokine ligand 11
Alias:
- CC motif chemokine 11
- chemokine (CC motif) ligand 11
- eosinophil chemotactic protein
- eotaxin
- eotaxin-1
- MGC22554
- SCYA11
- small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin)
- small-inducible cytokine A11
Gene sequence:NCBI_Gene: 6356
Protein sequence:UniProtKB: P51671
Human CCL11 target molecular function (prediction)
Enables CCR3 chemokine receptor binding activity; chemokine activity; and protein dimerization activity. Involved in several processes, including eosinophil chemotaxis; positive regulation of GTPase activity; and positive regulation of actin filament polymerization. Located in extracellular region. Implicated in asthma; human immunodeficiency virus infectious disease; and hyperglycemia. Biomarker of several diseases, including cystic fibrosis; hyperglycemia; lung disease (multiple); nephrotic syndrome type 1; and ureteral obstruction.
Mouse Ccl11 molecular target information
Molecular name: Ccl11, chemokine (CC motif) ligand 11
Alternate names:
- eotaxin
- Scya11
- small inducible cytokine A11
Gene sequence:NCBI_Gene: 20292
Protein sequence:
Mouse Ccl11 target molecular function (prediction)
Predicted to enable CCR3 chemokine receptor binding activity; chemokine activity; and protein dimerization activity. Involved in several processes, including modulation of age-related behavioral decline; negative regulation of neurogenesis; and positive regulation of angiogenesis. Acts upstream of or within branching involved in mammary gland duct morphogenesis and mammary duct terminal end bud growth. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in embryo; endocardial lining; liver parenchyma; liver vasculature; and yolk sac blood vessel. Human ortholog(s) of this gene implicated in asthma; human immunodeficiency virus infectious disease; hyperglycemia; and multiple sclerosis. Orthologous to several human genes including CCL11 (CC motif chemokine ligand 11).
Rat Ccl11 molecular target information
Molecular name: Ccl11, CC motif chemokine ligand 11
Alias:
- CC motif chemokine 11
- chemokine (CC motif) ligand 11
- eosinophil chemotactic protein
- eotaxin
- Scya11
- small inducible cytokine A11
- small inducible cytokine subfamily A11
- small-inducible cytokine A11
Gene sequence:NCBI_Gene: 29397
Protein sequence:UniProtKB: P97545
Rat Ccl11 target molecular function (prediction)
Enables chemokine activity. Involved in several processes, including ERK1 and ERK2 cascade; leukocyte chemotaxis; and response to interleukin-13. Located in extracellular space. Used to study allergic rhinitis; asthma; pleurisy; and pneumonia. Biomarker of several diseases, including allergic conjunctivitis; pneumonia; prostatitis; rhinitis; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in asthma; human immunodeficiency virus infectious disease; hyperglycemia; and multiple sclerosis. Orthologous to several human genes including CCL11 (CC motif chemokine ligand 11).