Blog

Overview of LEP molecular target information


  • Molecular name: LEP, leptin
  • Gene family: Neuropeptides
  • Former name: OBS; OB
  • Alias: leptin (murine obesity homolog); leptin (obesity homolog, mouse)


    • Overview of LEP molecular targets


    Leptin is a protein hormone secreted by fat cells that regulates energy balance by suppressing hunger. In addition to white adipose tissue, brown fat, placenta, ovary, skeletal muscle, stomach, mammary epithelial cells, bone marrow and P/D1 cells can also produce leptin. Both leptin and ghrelin act on receptors in the arcuate nucleus of the hypothalamus to regulate appetite and achieve energy balance. The basic function of leptin is to regulate fat storage, but it also plays a role in other physiological metabolic processes, but many other functions are not yet clear. Studies have shown that leptin is associated with obesity and weight loss.


    Human LEP molecular target information


    Molecular name: LEP, leptin


    Alias:

    • FLJ94114
    • LEPD
    • leptin (murine obesity homolog)
    • leptin (obesity homolog, mouse)
    • OB
    • obese protein
    • obese, mouse, homolog of
    • obesity factor
    • OBS

    Gene sequence:NCBI_Gene: 3952

    Protein sequence: UniProtKB: P41159


    Human LEP target molecular function (prediction)


    Enables leptin receptor binding activity. Involved in several processes, including positive regulation of signal transduction; regulation of cytokine production; and regulation of lymphocyte proliferation. Predicted to be located in cytosol. Predicted to be active in extracellular space. Implicated in several diseases, including alcohol dependence; congenital leptin deficiency; liver disease (multiple); lung disease (multiple); and type 2 diabetes mellitus. cystic fibrosis; fatty liver disease (multiple); liver disease (multiple); and lung disease (multiple).


    Mouse Lep molecular target information


    Molecular name: Lep, leptin


    Alias:

    • ob
    • obese


    Gene sequence:NCBI_Gene: 16846

    Protein sequence:


    Mouse Lep target molecular function (prediction)


    Acts upstream of or within several processes, including insulin secretion; monocarboxylic acid metabolic process; and regulation of insulin secretion. Located in cytoplasm and extracellular space. Is expressed in several structures, including adipose tissue; alimentary system; central nervous system; early conceptus; and genitourinary system. Used to study abdominal obesity-metabolic syndrome (multiple); fatty liver disease (multiple); obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; congenital leptin deficiency; liver disease (multiple); lung disease (multiple); and type 2 diabetes mellitus. Orthologous to human LEP (leptin).


    Rat Lep molecular target information


    Molecular name: Lep, leptin

    Alias:

    • OB
    • obese
    • obesity (murine homolog leptin)
    • obesity factor

    Gene sequence:NCBI_Gene: 25608

    Protein sequence:


    Rat Lep target molecular function (prediction)


    Enables hormone activity and peptide hormone receptor binding activity. Involved in several processes, including positive regulation of cell communication; regulation of apoptotic process; and response to vitamin. Located in cytosol and extracellular space. Used to study several diseases, including alcohol dependence; glucose metabolism disease (multiple); liver disease (multiple); neurodegenerative disease (multiple); lipid metabolism disorder (multiple); and obesity. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; congenital leptin deficiency; fatty liver disease (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human LEP (leptin).