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TNFSF12 molecular target information overview


  • Molecular name: TNFSF12, TNF superfamily member 12
  • Gene family: Tumor necrosis factor superfamily
  • Alias: TWEAK; DR3LG; APO3L
  • Alias: tumor necrosis factor (ligand) superfamily, member 12


    • Overview of TNFSF12 molecular targets


    Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) was discovered in 1997. The protein encoded by the TWEAK gene is a cytokine in the tumor necrosis factor (TNF) ligand family. Leukocytes (including human resting and activated monocytes, dendritic cells, and natural killer cells) are the main source of TWEAK. Depending on the cell type, TWEAK can induce apoptosis through multiple pathways and can also promote the proliferation and migration of endothelial cells, thereby regulating angiogenesis. In chronic injuries, overactivated TWEAK pathways can promote pathological tissue changes, including chronic inflammation, fibrosis, and angiogenesis.


    Human TNFSF12 Molecular Target Information


    Molecular name: TNFSF12, TNF superfamily member 12


    Alias:

    • APO3 ligand
    • APO3/DR3 ligand
    • APO3L
    • DR3LG
    • MGC129581
    • MGC20669
    • TNF-related WEAK inducer of apoptosis
    • TNLG4A
    • tumor necrosis factor (ligand) superfamily member 12
    • tumor necrosis factor (ligand) superfamily member 12
    • tumor necrosis factor ligand 4A
    • tumor necrosis factor ligand superfamily member 12
    • tumor necrosis factor superfamily member 12
    • TWEAK

    Gene sequence:NCBI_Gene: 8742

    Protein sequence: UniProtKB: O43508


    Human TNFSF12 target molecular function (prediction)


    Predicted to enable receptor ligand activity. Involved in positive regulation of extrinsic apoptotic signaling pathway. Acts upstream of or within positive regulation of protein catabolic process. Located in perinuclear region of cytoplasm.


    Mouse Tnfsf12 molecular target information


    Molecular name:Tnfsf12, tumor necrosis factor (ligand) superfamily, member 12


    Alias:

    • APO3L
    • DR3L
    • TNF-related weak inducer of apoptosis
    • Tweak


    Gene sequence:NCBI_Gene: 21944

    Protein sequence:


    Mouse Tnfsf12 target molecular function (prediction)


    Predicted to enable receptor ligand activity. Acts upstream of or within extrinsic apoptotic signaling pathway. Located in extracellular region. Is expressed in Meckel's cartilage; hip; skeleton; and superior cervical ganglion. Orthologous to several human genes including TNFSF12-TNFSF13 (TNFSF12-TNFSF13 readthrough).


    Rat Tnfsf12 molecular target information


    Molecular name: Tnfsf12, TNF superfamily member 12

    Alias:

    • TNF-related weak inducer of apoptosis
    • Tnlg4a
    • tumor necrosis factor ligand 4a
    • tumor necrosis factor ligand superfamily member 12
    • tumor necrosis factor superfamily member 12
    • TWEAK

    Gene sequence:NCBI_Gene: 360548

    Protein sequence:


    Rat Tnfsf12 target molecular function (prediction)


    Predicted to enable receptor ligand activity. Predicted to be involved in extrinsic apoptotic signaling pathway and positive regulation of extrinsic apoptotic signaling pathway. Predicted to act upstream of or within positive regulation of protein catabolic process. Predicted to be located in extracellular region and perinuclear region of cytoplasm. Predicted to be active in extracellular space. (TNFSF12-TNFSF13 readthrough).