ENG Molecular Target Information Overview
ENG Molecular Targets Overview
Endoglin, also known as CD105, is a type I transmembrane glycoprotein located on the cell membrane surface and is one of the TGF-β receptor complexes. It is involved in regulating responses to binding to TGF-β1, TGF-β3, Activin-A, BMP-2, and BMP-7. Endoglin is hypothesized to be involved in cytoskeletal organization that affects cell morphology and migration. It plays a role in cardiovascular system development and vascular remodeling. Endoglin expression is regulated during cardiac development. Laboratory mice lacking the Endoglin gene die due to cardiovascular abnormalities. In humans, Endoglin may be involved in autosomal dominant diseases, best known as hereditary hemorrhagic telangiectasia type 1 (HHT). It causes frequent epistaxis, cutaneous and mucosal telangiectasias, and arteriovenous malformations in different organs such as the brain, lungs, and liver.
Human ENG Molecular Target Information
Molecule name: ENG, endoglin
Alias:
- CD105
- CD105 antigen
- END
- FLJ41744
- HHT1
- ORW
- ORW1
Gene sequence:NCBI_Gene: 2022
Protein sequence:UniProtKB: P17813
Human ENG target molecular function (prediction)
Contributes to BMP binding activity and transforming growth factor beta binding activity. Involved in several processes, including central nervous system vasculogenesis; regulation of transcription by RNA polymerase II; and regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Located in external side of plasma membrane; extracellular space; and nuclear body. Part of receptor complex. Implicated in arteriovenous malformation; arteriovenous malformations of the brain; breast cancer; hereditary hemorrhagic telangiectasia; and intracranial aneurysm. Biomarker of several diseases, including artery disease (multiple); clear cell renal cell carcinoma; diabetic retinopathy; hematologic cancer (multiple); and secondary hyperparathyroidism.
Mouse Eng Molecular Target Information
Molecule name: Eng, endoglin
Alias:
- AI528660
- AI662476
- CD105
- Endo
- expressed sequence AI528660
- expressed sequence AI662476
Gene sequence:NCBI_Gene: 13805
Protein sequence:
- UniprotKB: Q63961
- UniprotKB: A9Z1A0
- UniprotKB: F7A1B4
- UniprotKB: F7BZW0
- UniprotKB: Q3UAM9
- UniprotKB: Q5IRN0
Mouse Eng Target molecular function (prediction)
Acts upstream of or within circulatory system development and positive regulation of angiogenesis. Located in endothelial microparticle. Is expressed in several structures, including brain; cardiovascular system; extraembryonic vascular system; and lung. Used to study arteriovenous malformations of the brain and hereditary hemorrhagic telangiectasia. Human ortholog(s) of this gene implicated in arteriovenous malformation; arteriovenous malformations of the brain; breast cancer; hereditary hemorrhagic telangiectasia; and intracranial aneurysm. Orthologous to human ENG (endoglin).
Rat Eng Molecular Target Information
Molecule name: Eng, endoglin
Alias:
- MGC124909
Gene sequence:NCBI_Gene: 497010
Protein sequence:
Rat Eng Target Molecular Function (Prediction)
Enables type II transforming growth factor beta receptor binding activity. Involved in several processes, including cellular response to mechanical stimulus; positive regulation of collagen biosynthetic process; and positive regulation of macromolecule metabolic process. Located in cell surface and extracellular space. Used to study congestive heart failure; pre-eclampsia; and renal fibrosis. Biomarker of cholestasis; congestive heart failure; hepatocellular carcinoma; hypertension (multiple); and renal fibrosis. Human Ortholog(s) of this gene implicated in arteriovenous malformation; arteriovenous malformations of the brain; breast cancer; hereditary hemorrhagic telangiectasia; and intracranial aneurysm. Orthologous to human ENG (endoglin).