IL1B molecular target information overview
Overview of IL1B molecular targets
Interleukin 1 (IL-1) is a 17 kDa extracellular polypeptide that is divided into two proteins, IL-1α and IL-1β. IL-1β is a protein precursor secreted by activated macrophages and is produced as an activated form by hydrolysis by caspase1 (CASP1/ICE). This cytokine is an important mediator of inflammatory responses and is involved in many cellular activities, including cell proliferation, differentiation, and apoptosis. IL-1 is an important family of proteins that are derived from biologically activated monocytes and participate in inflammatory and immune responses. Elevated expression of IL-1β can produce a variety of different autoinflammatory syndromes, the most notable of which is a monogenic condition called CAPS, which is caused by mutations in the inflammasome receptor NLRP3 that triggers IL-1β processing. This kit is used to detect the mature form and uncleaved precursor form of human IL-1β.
Human IL1B Molecular Target Information
Molecular name: IL1B, interleukin 1 beta
Alias:
- catabolin
- IL-1
- IL-1 beta
- IL1-BETA
- IL1beta
- IL1F2
- interleukin 1, beta
- interleukin 1beta
- interleukin-1 beta
- preinterleukin 1 beta
- pro-interleukin-1-beta
Gene sequence:NCBI_Gene: 3553
Protein sequence: UniProtKB: P01584
Human IL1B target molecular function (prediction)
Enables cytokine activity; integrin binding activity; and protein domain specific binding activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of nitrogen compound metabolic process; and regulation of signal transduction. Acts upstream of or within cellular response to organic substance and cellular response to xenobiotic stimulus. Located in extracellular space. Implicated in several diseases, including autoimmune disease (multiple); blood platelet disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); and lung disease (multiple). Biomarker of several diseases, including artery disease (multiple); autoimmune disease (multiple); bronchial disease (multiple); lung disease (multiple); and nose disease (multiple).
Mouse Il1b molecular target information
Molecular name: Il1b, interleukin 1 beta
Alias:
- IL-1B
- Il-1b
- IL-1beta
Gene sequence:NCBI_Gene: 16176
Protein sequence:
Mouse Il1b target molecular function (prediction)
Acts upstream of or within several processes, including ectopic germ cell programmed cell death; positive regulation of intracellular signal transduction; and positive regulation of macromolecule metabolic process. Located in extracellular space and secretory granule. Is expressed in several structures, including dorsal aorta; early conceptus; hemolymphoid system; integument; and reproductive Orthologous to human IL1B (interleukin 1 beta). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); blood platelet disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); and lung disease (multiple).
Rat Il1b molecular target information
Molecular name: Il1b, interleukin 1 beta
Alias:
- IL-1 beta
- IL-1F2
- interleukin-1 beta
Gene sequence:NCBI_Gene: 24494
Protein sequence:
Rat Il1b target molecular function (prediction)
Enables cytokine activity. Involved in several processes, including positive regulation of intracellular signal transduction; regulation of gene expression; and regulation of neurogenesis. Located in extracellular space. Used to study several diseases, including artery disease (multiple); brain disease (multiple); glomerulonephritis (multiple); interstitial lung disease (multiple); and kidney failure (multiple). brain disease (multiple); kidney failure (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); blood platelet disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); and lung disease (multiple). Orthologous to human IL1B (interleukin 1 beta).