LCN2 Molecular Target Information Overview
LCN2 molecular target review
Lipocalin-2, also known as neutrophil gelatinase-associated lipocalin (NGAL) or oncogene 24p3, is expressed in neutrophils and at low levels in epithelial cells of the kidney, prostate, respiratory tract, and digestive tract. Lipocalin-2 participates in innate immunity by chelating iron, which in turn limits bacterial growth. Lipocalin-2 is a biomarker for kidney injury and can also be used as an early diagnostic for chronic kidney disease, contrast-induced nephropathy, and kidney transplantation. Within 2 hours of acute kidney injury (AKI), high levels of Lipocalin-2 are secreted into the blood and urine. The body's Lipocalin-2 level is proportional to the severity of AKI.
Human LCN2 Molecular Target Information
Molecular name: LCN2, lipocalin 2
Alias:
- 24p3
- 25 kDa alpha-2-microglobulin-related subunit of MMP-9
- lipocalin-2
- migration-stimulating factor inhibitor
- MSFI
- neutrophil gelatinase-associated lipocalin
- NGAL
- oncogene 24p3
- p25
- siderocalin
- siderocalin LCN2
Gene sequence:NCBI_Gene: 3934
Protein sequence:UniProtKB: P80188
Human LCN2 target molecular function (prediction)
Enables enterobactin binding activity; identical protein binding activity; and iron ion binding activity. Involved in defense response to bacterium and sequestering of iron ion. Located in extracellular space. Implicated in urinary tract infection. Biomarker of several diseases, including congenital diaphragmatic hernia; hidradenitis suppurativa; hydronephrosis; hypertension (multiple); and kidney disease (multiple).
Mouse Lcn2 molecular target information
Molecular name: Lcn2, lipocalin 2
Alias:
- 24p3
- AW212229
- expressed sequence AW212229
- neu-related lipocalin
- NGAL
- NRL
Gene sequence:NCBI_Gene: 16819
Protein sequence:
Mouse Lcn2 target molecular function (prediction)
Enables iron ion binding activity. Involved in innate immune response; positive regulation of cold-induced thermogenesis; and siderophore transport. Acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand; response to bacterium; and response to virus. Located in extracellular space. Is expressed in several structures, including genitourinary system; gut; liver; lung; and spleen. Human ortholog(s) of this gene implicated in intrahepatic cholangiocarcinoma and urinary tract infection. Orthologous to human LCN2 (lipocalin 2).
Rat Lcn2 molecular target information
Molecular name: Lcn2, lipocalin 2
Synonyms:
- alpha-2-microglobulin-related protein
- alpha-2U globulin-related protein
- lipocalin 2 (oncogene 24p3)
- lipocalin 24p3
- lipocalin-2
- neutrophil gelatinase-associated lipocalin
- NGAL
- p25
- siderocalin LCN2
- Sip24
Gene sequence:NCBI_Gene: 170496
Protein sequence:UniProtKB: P30152
Rat Lcn2 target molecular function (prediction)
Enables enterobactin binding activity; identical protein binding activity; and protease binding activity. Involved in several processes, including cellular response to cytokine stimulus; memory; and regulation of neuron apoptotic process. Located in cytosol and extracellular space. Used to study intrahepatic cholangiocarcinoma and retinal degeneration. Biomarker of several diseases, including acute kidney failure; congenital diaphragmatic hernia; obesity; pulmonary hypertension; and transient cerebral ischemia. Human Ortholog(s) of this gene implicated in urinary tract infection. Orthologous to human LCN2 (lipocalin 2).