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Overview of AGER molecular targets

The receptor for advanced glycation end products (RAGE) is a 35 kDa immunoglobulin superfamily transmembrane receptor that gets its name from its ability to bind to advanced glycation end products. Given its inflammatory function in innate immunity and its ability to recognize a class of ligands through a common motif, RAGE is generally considered a class of recognition receptors. RAGE is associated with several chronic diseases, such as atherosclerosis, peripheral vascular disease, myocardial infarction, congestive heart failure, diabetes, and Alzheimer's disease. Compared with other tissues, RAGE is most highly expressed in the lungs, especially in type I alveolar epithelial cells, but is not expressed in idiopathic pulmonary fibrosis (IPF), suggesting that the expression and regulation of RAGE in the lung system is different from that in the cardiovascular system. Blocking/knockout of RAGE results in impaired cell adhesion and increased cell proliferation and migration.

Human AGER molecular target information

Molecular name:AGER, advanced glycosylation end-product specific receptor

Synonyms:

• advanced glycosylation end product-specific receptor
• MGC22357
• RAGE
• RAGE isoform delta
• RAGE isoform NtRAGE-delta
• RAGE isoform sRAGE-delta
• receptor for advanced glycation end-products variant 20
• receptor for advanced glycosylation end products
• receptor for advanced glycosylation end-products
• SCARJ1
• sRAGE

Gene sequence:NCBI_Gene: 177

Protein sequence:UniProtKB: Q15109

Human AGER target molecular function (prediction)

Enables several functions, including S100 protein binding activity; amyloid-beta binding activity; and identical protein binding activity. Involved in several processes, including modulation of chemical synaptic transmission; positive of intracellular signal transduction; and positive regulation of macromolecule metabolic process. Located in apical plasma membrane; cell junction; and fibrillar center. Implicated in several diseases, including autoimmune disease (multiple); cardiovascular system disease (multiple); cystic fibrosis; kidney failure (multiple); and lupus nephritis. Biomarker of several diseases, including artery disease (multiple); chronic kidney disease (multiple); congestive heart failure (multiple); diabetic retinopathy (multiple); and lung disease (multiple).

Mouse Ager molecular target information

Molecular name:Ager, advanced glycosylation end product-specific receptor

Alias:

• RAGE

Gene sequence:NCBI_Gene: 11596

Protein sequence:

• UniprotKB: Q62151
• UniprotKB: F1ABR7
• UniprotKB: F1ABR8
• UniprotKB: F1ABR9
• UniprotKB: F1ABS0
• UniprotKB: F1ABS1
• UniprotKB: F1ABS2

Mouse Ager target molecular function (prediction)

Enables S100 protein binding activity; advanced glycation end-product binding activity; and heparin binding activity. Involved in several processes, including cellular response to amyloid-beta; negative regulation of long-term synaptic potentiation; and positive regulation of cytokine production. Acts upstream of or within several processes, including induction of positive chemotaxis; negative regulation of advanced glycation end-product receptor activity; expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and lung. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cardiovascular system disease (multiple); cystic fibrosis; kidney failure (multiple); and lupus nephritis. Orthologous to human AGER (advanced glycosylation end-product specific receptor).

Rat Ager molecular target information

Molecular name:Ager, advanced glycosylation end product-specific receptor

Synonyms:

• advanced glycosylation end product-specific receptor variant 2
• advanced glycosylation end product-specific receptor variant 3
• advanced glycosylation end product-specific receptor variant 4
• advanced glycosylation end product-specific receptor variant 5
• RAGE
• receptor for advanced glycosylation end products

Gene sequence:NCBI_Gene: 81722

Protein sequence:

• UniprotKB: A0A0G2K218
• UniprotKB: A0A0G2K653
• UniprotKB: A0A0G2KAP4
• UniprotKB: F1ABR3
• UniprotKB: F1ABR4
• UniprotKB: F1ABR5
• UniprotKB: F1ABR6
• UniprotKB: M0RAU0
• UniprotKB: Q63495
• UniprotKB: Q6MG86

Rat Ager target molecular function (prediction)

Enables S100 protein binding activity and high mobility group box 1 binding activity. Involved in several processes, including positive regulation of apoptotic process; regulation of cell migration; and response to hexose. Located in several cellular components, including basal plasma membrane; cell surface; and neuronal cell body. Used to study several diseases, including diabetic retinopathy; impotence; renal fibrosis; thromboangiitis obliterans; and type 2 diabetes mellitus. Biomarker of Orthologous to human AGER (advanced glycosylation end-product specific) several diseases, including bone disease (multiple); cardiovascular system disease (multiple); colorectal carcinoma; diabetic encephalopathy; and lung disease (multiple). receptor).