NRG1 molecular target information overview
Overview of NRG1 molecular targets
Neuregulin 1 (NRG1) was originally identified as a 44 kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase phosphorylation of tyrosine residues. Various isoforms are generated from the NRG1 gene through alternative splicing. These isoforms include heregulins (HRGs), nerve growth factors (GGFs), and sensory and motor neuron-derived factors (SMDFs). Neuregulin and its various isoforms are from a family of four structurally related proteins that are part of the EGF protein family. These proteins play multiple roles not only in the development of the nervous system but also in the development of vertebrate embryos, including heart development, neurolemma and oligodendrocyte differentiation, some aspects of neural development, and the formation of neuromuscular synapses.
Human NRG1 Molecular Target Information
Molecular name: NRG1, neuregulin 1
Alias:
- acetylcholine receptor-inducing activity
- ARIA
- GGF
- GGF2
- glial growth factor
- glial growth factor 2
- heregulin, alpha (45kD, ERBB2 p185-activator)
- HGL
- HRG
- HRG1
- HRGA
- MST131
- MSTP131
- NDF
- neu differentiation factor
- neuregulin 1 type IV beta 1a
- neuregulin 1 type IV beta 3
- NRG1 intronic transcript 2 (non-protein coding)
- NRG1-IT2
- pro-neuregulin-1, membrane-bound isoform
- pro-NRG1
- sensory and motor neuron derived factor
- SMDF
Gene sequence:NCBI_Gene: 3084
Protein sequence:UniProtKB: Q02297
Human NRG1 target molecular function (prediction)
Enables protein tyrosine kinase activator activity; signaling receptor binding activity; and transcription coregulator activity. Involved in several processes, including ERBB signaling pathway; heart development; and positive regulation of protein phosphorylation. Acts upstream of or within cellular protein complex disassembly and negative regulation of transcription, DNA-templated. Located in apical plasma membrane; extracellular space; and noplasm. Is active in glutamatergic synapse. postsynaptic density membrane and integral component of presynaptic active zone membrane. Implicated in several diseases, including bipolar disorder; cerebral malaria; dementia; middle cerebral artery infarction; and psychotic disorder (multiple). Biomarker of Alzheimer's disease; hepatocellular carcinoma; major depressive disorder; and ovarian cancer.
Mouse Nrg1 molecular target information
Molecular name: Nrg1, neuregulin 1
Alias:
- 6030402G23Rik
- ARIA
- D230005F13Rik
- GGF
- GGFII
- heregulin
- Hgl
- HGL
- HRG
- HRGalpha
- NDF
- RIKEN cDNA 6030402G23 gene
- RIKEN cDNA D230005F13 gene
- SMDF
Gene sequence:NCBI_Gene: 211323
Protein sequence:
- UniprotKB: A0A140LHD8
- UniprotKB: A0A140LHG5
- UniprotKB: A0A140LHN1
- UniprotKB: A0A140LHQ6
- UniprotKB: A0A140LHZ9
- UniprotKB: A0A140LIG9
- UniprotKB: A0A140LIJ3
- UniprotKB: A0A140LIK5
- UniprotKB: A0A140LIP8
- UniprotKB: A0A140LJ88
- UniprotKB: A0A140LJC1
- UniprotKB: A0A5F8MP73
- UniprotKB: A0A5F8MPA3
- UniprotKB: A0A5F8MPD1
- UniprotKB: A0A5F8MPJ0
- UniprotKB: A0A5F8MPL7
- UniprotKB: A0A5F8MPM6
- UniprotKB: A0A5F8MPT0
- UniprotKB: A0A5F8MPT8
- UniprotKB: A0A5F8MPU1
- UniprotKB: A0A5F8MPU8
- UniprotKB: A0A5F8MQ03
- UniprotKB: A0A5F8MQ49
- UniprotKB: Q3TD94
- UniprotKB: Q3URY7
- UniprotKB: Q6DR98
- UniprotKB: Q6DR99
- UniprotKB: Q810X0
- UniprotKB: Q8BX76
Mouse Nrg1 target molecular function (prediction)
Enables ErbB-2 class receptor binding activity and chemorepellent activity. Involved in several processes, including positive regulation of cardiac muscle cell differentiation; postsynapse to nucleus signaling pathway; and synapse assembly. Acts upstream of or within several processes, including neurogenesis; positive regulation of intracellular signal transduction; and positive regulation of macromolecule metabolic process. Located in several cellular components, including axolemma; external side of plasma membrane; and neuromuscular junction. Is integral component of plasma membrane. Is active in GABA-ergic synapse and glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Used to study schizophrenia. Human ortholog(s) of this gene implicated in several diseases, including bipolar disorder; cerebral malaria; dementia; middle cerebral artery infarction; and psychotic disorder (multiple). Orthologous to human NRG1 (neuregulin 1).
Rat Nrg1 molecular target information
Molecular name: Nrg1, neuregulin 1
Alias:
- glial growth factor
- neuregulin 1 type III beta 3
- pro-neuregulin-1, membrane-bound isoform
- pro-NRG1
Gene sequence:NCBI_Gene: 112400
Protein sequence:
- UniprotKB: A0A0G2K057
- UniprotKB: A0A0G2K3Q3
- UniprotKB: D3ZC94
- UniprotKB: D4ACB2
- UniprotKB: G3V7D6
- UniprotKB: G3V7F0
- UniprotKB: G3V9Q0
- UniprotKB: P43322
- UniprotKB: Q3S2T6
- UniprotKB: Q52R82
- UniprotKB: Q9ESA1
- UniprotKB: Q9ESA2
- UniprotKB: Q9ESA3
- UniprotKB: Q9ESA4
- UniprotKB: Q9ESA5
- UniprotKB: Q9ESA6
- UniprotKB: Q9ESA7
- UniprotKB: Q9ESA8
- UniprotKB: Q9ESA9
- UniprotKB: Q9ESB0
- UniprotKB: Q9ESB1
Rat Nrg1 target molecular function (prediction)
Enables receptor tyrosine kinase binding activity. Involved in several processes, including negative regulation of corticosterone secretion; positive regulation of Schwann cell proliferation; and response to progesterone. Located in extracellular space and synapse. Used to study sciatic neuropathy. Biomarker of diabetic neuropathy; median neuropathy; schizophrenia; and visual epilepsy. Human ortholog(s) of this gene implicated in several diseases, including bipolar disorder; cerebral malaria; dementia; middle cerebral artery infarction; and psychotic disorder (multiple). Orthologous to human NRG1 (neuregulin 1).