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GZMA molecular target information overview


  • Molecular name: GZMA, granzyme A
  • Gene family: Granule associated serine proteases of immune defense
  • Previous names: HFSP; CTLA3
  • Alias: CTL tryptase; Cytotoxic T-lymphocyte-associated serine esterase-3; Hanukah factor serine protease); granzyme 1; granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)


    • Overview of GZMA molecular targets


    Granzyme A is a member of the granzyme family of serine proteases and is found exclusively in the granules of cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. Granzyme A is the most abundant protease in CTL and NK cells. It enters target cells via perforin and induces caspase-independent cell death. Upon activation by lysyl endopeptidase, Granzyme A cleaves thioester substrates. Human Granzyme A is synthesized as a precursor (262 residues) with a signal peptide (residues 1-26), a propeptide (residues 27-28), and a mature chain (residues 29-262). Purified recombinant human Granzyme A consists of residues 26-262.


    Human GZMA Molecular Target Information


    Molecular name: GZMA, granzyme A


    Alias:

    • CTL tryptase
    • CTLA3
    • cytotoxic T-lymphocyte proteinase 1
    • cytotoxic T-lymphocyte-associated serine esterase-3
    • fragmentin-1
    • granzyme 1
    • Granzyme A (Cytotoxic T-lymphocyte-associated serine esterase-3
      • serine esterase-3, Hanukah factor serine protease)
    • granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
    • granzyme-1
    • h factor
    • hanukah factor serine protease
    • Hanukah factor serine protease)
    • hanukkah factor
    • HF
    • HFSP

    Gene sequence:NCBI_Gene: 3001

    Protein sequence:UniProtKB: P12544


    Human GZMA target molecular function (prediction)


    Enables protein homodimerization activity and serine-type endopeptidase activity. Involved in several processes, including cytotoxic T cell pyroptotic process; granzyme-mediated programmed cell death signaling pathway; and negative regulation of endodeoxyribonuclease activity. Predicted to be located in immunological synapse and nucleus. Biomarker of chronic obstructive pulmonary disease.


    Mouse Gzma molecular target information


    Molecular name: Gzma, granzyme A


    Alias:

    • AW494114
    • BLT esterase
    • Ctla-3
    • Ctla3
    • cytotoxic T lymphocyte-associated protein 3
    • expressed sequence AW494114
    • H factor
    • Hanukah factor
    • Hf
    • SE1
    • serine esterase 1
    • TSP-1
    • TSP1


    Gene sequence:NCBI_Gene: 14938

    Protein sequence:


    Mouse Gzma target molecular function (prediction)


    Enables serine-type peptidase activity. Acts upstream of or within response to bacterium. Located in nucleus. Is expressed in thymus primordium. Orthologous to human GZMA (granzyme A).


    Rat Gzma molecular target information


    Molecular name: Gzma, granzyme A

    Alias:

    • None

    Gene sequence:NCBI_Gene: 266708

    Protein sequence:


    Rat Gzma target molecular function (prediction)


    Predicted to enable protein homodimerization activity and serine-type endopeptidase activity. Predicted to be involved in several processes, including cytotoxic T cell pyroptotic process; granzyme-mediated programmed cell death signaling pathway; and negative regulation of endodeoxyribonuclease activity. Predicted to act upstream of or within response to bacterium. Predicted to be located in nucleus. Orthologous to human GZMA (granzyme A).