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ZAP70 molecular target information overview


  • Molecular name: ZAP70, zeta chain of T cell receptor associated protein kinase 70
  • Gene family: SH2 domain containing; Syk family tyrosine kinases
  • Alias: ZAP-70; STD
  • Former name: SRK
  • Alias: tyrosine-protein kinase ZAP-70; SRK


    • Overview of ZAP70 molecular targets


    TCR-associated protein-70, expressed in T cells and NK cells, is required for TCR signaling and development. ZAP-70 interacts with the TCR complex by binding to ITAMs present in the invariant subunits of the TCR complex. Upon activation, ZAP-70 is phosphorylated on several tyrosine residues by two mechanisms: autophosphorylation and trans-phosphorylation by the Src family tyrosine kinases Lck1-3. Tyrosine phosphorylation of ZAP-70 is associated with its increased kinase activity and triggers downstream signaling events. Although ZAP-70 is usually expressed in T cells and NK cells, several recent studies have also shown that ZAP-70 positive expression is highly correlated with the expression of mutant IgVH in B chronic lymphocytic leukemia (CCL). In conclusion, the expression of ZAP-70 can be measured by intracellular flow cytometry and can serve as a prognostic marker for B-CLL.


    Human ZAP70 Molecular Target Information


    Molecular name:ZAP70, zeta chain of T cell receptor associated protein kinase 70


    Alias:

    • 70 kDa zeta-associated protein
    • 70 kDa zeta-chain associated protein
    • ADMIO2
    • FLJ17670
    • FLJ17679
    • IMD48
    • SRK
    • STCD
    • STD
    • syk-related tyrosine kinase
    • tyrosine-protein kinase ZAP-70
    • TZK
    • ZAP-70
    • zeta chain of T cell receptor associated protein kinase 70kDa
    • zeta chain of T-cell receptor associated protein kinase 70
    • zeta-chain (TCR) associated protein kinase 70kDa
    • zeta-chain associated protein kinase, 70kD

    Gene sequence:NCBI_Gene: 7535

    Protein sequence:UniProtKB: P43403


    Human ZAP70 target molecular function (prediction)


    Enables non-membrane spanning protein tyrosine kinase activity and phosphotyrosine residue binding activity. Involved in immune response and protein phosphorylation. Acts upstream of or within peptidyl-tyrosine phosphorylation; positive regulation of T cell differentiation; and positive thymic T cell selection. Located in plasma membrane. Part of T cell receptor complex. Colocalizes with membrane raft. Implicated in immunodeficiency 48 and severe combined immunodeficiency.


    Mouse Zap70 molecular target information


    Molecular Name: Zap70, zeta-chain (TCR) associated protein kinase


    Alias:

    • AI327364
    • expressed sequence AI327364
    • mr t-less
    • mrtle
    • mur
    • murdoch
    • Srk
    • syk related kinase
    • TZK
    • ZAP-70


    Gene sequence:NCBI_Gene: 22637

    Protein sequence:


    Mouse Zap70 target molecular function (prediction)


    Enables ATP binding activity; phosphotyrosine residue binding activity; and protein tyrosine kinase activity. Acts upstream of or within several processes, including T cell selection; positive regulation of alpha-beta T cell activation; and protein phosphorylation. Located in cell-cell junction; cytosol; and immunological synapse. Is expressed in brain; gut; hemolymphoid system gland; liver; and lung epithelium. Used to study rheumatoid arthritis. Human Ortholog(s) of this gene implicated in immunodeficiency 48 and severe combined immunodeficiency. Orthologous to human ZAP70 (zeta chain of T cell receptor associated protein kinase 70).


    Rat Zap70 molecular target information


    Molecular name:Zap70, zeta chain of T cell receptor associated protein kinase 70

    Alias:

    • MGC108902
    • Srk
    • syk-related protein tyrosine kinase
    • tyrosine-protein kinase ZAP-70
    • Zap70_mapped
    • zeta-chain (TCR) associated protein kinase
    • zeta-chain (TCR) associated protein kinase 70
    • zeta-chain (TCR) associated protein kinase 70 (mapped)
    • zeta-chain (TCR) associated protein kinase 70kDa

    Gene sequence:NCBI_Gene: 301348

    Protein sequence:UniProtKB: A0A0R4J8U1


    Rat Zap70 target molecular function (prediction)


    Predicted to enable several functions, including ATP binding activity; non-membrane spanning protein tyrosine kinase activity; and phosphotyrosine residue binding activity. Predicted to be involved in cell differentiation; innate immune response; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within several processes, including T cell selection; positive regulation of alpha-beta T cell activation; and protein phosphorylation. Predicted to be located in cell-cell junction; cytosol; and immunological synapse. Predicted to be part of T cell receptor complex. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Predicted to colocalize with membrane raft. Human ortholog(s) of this gene implicated in immunodeficiency 48 and severe combined immunodeficiency. Orthologous to human ZAP70 (zeta chain of T cell receptor associated protein kinase 70).