Overview of APOD molecular target information
Overview of APOD molecular targets
Apolipoprotein D (Apo D) is a glycoprotein of approximately 33 kDa, encoded in humans by the APOD gene. Unlike other lipoproteins, which are produced primarily in the liver, Apo D is produced primarily in the brain and testes. It is a component of high-density lipoprotein (HDL) and has no significant sequence similarity to other apolipoproteins. Apo D is closely associated with phosphatidylcholine:cholesterol acyltransferase, which is involved in lipoprotein metabolism. Apo D is also an important link in the transient interaction between HDL and LDL particles, and between HDL particles and cells. Apo D is a biomarker for androgen insensitivity syndrome (AIS), which is associated with neurological disorders and neurological damage, especially myelin. Apo D levels are elevated in rat models of stroke. Apo D levels are elevated in patients with schizophrenia, bipolar disorder, and Alzheimer's disease.
Human APOD molecular target information
Molecular name: APOD, apolipoprotein D
Other Names:
- apo-D
Gene sequence:NCBI_Gene: 347
Protein sequence:UniProtKB: P05090
Human APOD target molecular function (prediction)
Enables cholesterol binding activity. Involved in several processes, including negative regulation of cell-matrix adhesion; negative regulation of macromolecule metabolic process; and negative regulation of protein import into nucleus. Located in extracellular space and perinuclear region of cytoplasm. Implicated in obesity and type 2 diabetes mellitus. Biomarker of Alzheimer's disease; gestational diabetes; and type 2 diabetes mellitus.
Mouse Apod molecular target information
Molecular name: Apod, apolipoprotein D
Alias:
- None
Gene sequence:NCBI_Gene: 11815
Protein sequence:
Mouse Apod target molecular function (prediction)
Predicted to enable cholesterol binding activity. Involved in negative regulation of lipoprotein lipid oxidation and response to reactive oxygen species. Predicted to be located in several cellular components, including cytosolic ribosome; neuronal cell body; and perinuclear region of cytoplasm. obesity and type 2 diabetes mellitus. Orthologous to human APOD (apolipoprotein D).
Rat Apod molecular target information
Molecular name: Apod, apolipoprotein D
Alias:
- AOPDGN
- apo-D
Gene sequence:NCBI_Gene: 25239
Protein sequence:
Rat Apod target molecular function (prediction)
Predicted to enable cholesterol binding activity. Involved in several processes, including aging; nervous system development; and tissue regeneration. Located in several cellular components, including cytosolic ribosome; dendrite;