TGFB1 molecular target information overview
Overview of TGFB1 molecular targets
Transforming growth factor β1 (TGF-β1) is a polypeptide member of the transforming growth factor β superfamily with multiple cellular functions, including regulation of cell growth, proliferation, differentiation, and apoptosis. TGF-β cooperates with TGFA to induce transformation. It can also act as a negative autocrine growth factor. Dysregulation of TGF-β activation and signaling may cause apoptosis. Many cells can synthesize TGF-β, and almost all have specific receptors. TGF-β1, TGF-β2, and TGF-β3 all function through the same receptor signaling pathway. TGF-β1 plays an important role in regulating the immune system and has different activities on different types of cells or cells at different developmental stages. Most immune cells (or white blood cells) secrete TGF-β1. TGF-β1 is associated with cancer, autoimmune diseases, liver disease, kidney disease, diabetes, cardiovascular disease, asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis (CF).
Human TGFB1 Molecular Target Information
Molecular name: TGFB1, transforming growth factor beta 1
Alias:
- CED
- DPD1
- IBDIMDE
- LAP
- latency-associated peptide
- prepro-transforming growth factor beta-1
- TGF-beta 1 protein
- TGF-beta-1
- TGF-beta1
- TGFB
- TGFbeta
- transforming growth factor beta-1
- transforming growth factor beta-1 proprotein
- transforming growth factor beta1
Gene sequence:NCBI_Gene: 7040
Protein sequence: UniProtKB: P01137
Human TGFB1 target molecular function (prediction)
Enables several functions, including antigen binding activity; identical protein binding activity; and transforming growth factor beta receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of macromolecule metabolic process; and positive regulation of signal transduction. Acts upstream of or within epithelial to mesenchymal transition; negative regulation of gene expression; and positive regulation of isotype switching to IgA isotypes. Located in several cellular components, including cell surface; extracellular space; and nucleus. Colocalizes with microvillus. Implicated in several diseases, including Behcet's disease; Camurati-Engelmann disease; aphthous stomatitis; artery disease (multiple); and lung disease (multiple).
Mouse Tgfb1 molecular target information
Molecular Name: Tgfb1, transforming growth factor, beta 1
Alias:
- TGF-beta 1
- TGF-beta1
- Tgfb
- Tgfb-1
- TGFbeta1
Gene sequence:NCBI_Gene: 21803
Protein sequence:
Mouse Tgfb1 target molecular function (prediction)
Acts upstream of or within several processes, including animal organ development; positive regulation of histone modification; and regulation of protein localization to nucleus. Located in cytoplasm; extracellular matrix; and extracellular space. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; heart; and skin. Used to study Sjogren's syndrome. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; Camurati-Engelmann disease; aphthous stomatitis; artery disease (multiple); and lung disease (multiple). Orthologous to human TGFB1 (transforming growth factor beta 1).
Rat Tgfb1 molecular target information
Molecular Name: Tgfb1, transforming growth factor, beta 1
Alias:
- TGF-beta-1
- Tgfb
- transforming growth factor beta-1
- transforming growth factor beta-1 proprotein
- transforming growth factor, beta-1
Gene sequence:NCBI_Gene: 59086
Protein sequence:UniProtKB: P17246
Rat Tgfb1 target molecular function (prediction)
Acts upstream of or within positive regulation of smooth muscle cell differentiation. Located in several cellular components, including cell surface; neuronal cell body; and secretory granule. Used to study chronic obstructive pulmonary disease; familial hyperlipidemia; hypertension; proteinuria; and pulmonary fibrosis. Biomarker of several diseases, including allergic rhinitis; artery disease (multiple); cerebrovascular disease (multiple); gastrointestinal system cancer (multiple); and lung disease (multiple). Orthologous to human TGFB1 (transforming growth factor beta 1).