BMP7 molecular target information overview
Overview of BMP7 molecular targets
Bone morphogenetic protein 7 (BMP-7) is a member of the TGF-β superfamily and is expressed in the brain, kidney, and bladder. It plays a key role in the transformation of mesenchymal cells into bone and cartilage. BMP-7 induces phosphorylation of SMAD1 and SMAD5, which in turn induces the transcription of osteogenic genes. In many cell types, BMP-7 treatment is sufficient to induce all genetic markers of osteoblast differentiation. BMP-7 has the potential to treat chronic kidney disease. In infertility that is refractory to FSH treatment, BMP-7 injections may be a therapeutic modality. BMP-7 may also be used as a treatment for obesity in humans.
Human BMP7 Molecular Target Information
Molecular name: BMP7, bone morphogenetic protein 7
Alias:
- BMP-7
- OP-1
- osteogenic protein 1
Gene sequence:NCBI_Gene: 655
Protein sequence: UniProtKB: P18075
Human BMP7 target molecular function (prediction)
Predicted to enable BMP receptor binding activity and cytokine activity. Involved in several processes, including regulation of gene expression; regulation of protein phosphorylation; and transmembrane receptor protein serine/threonine kinase signaling pathway. Acts upstream of or within negative regulation of neuron differentiation and neuron projection morphogenesis. Located in extracellular space. Implicated in prostate cancer. Biomarker of breast cancer; ovarian carcinoma; prostate cancer; and renal cell carcinoma.
Mouse Bmp7 molecular target information
Molecular name: Bmp7, bone morphogenetic protein 7
Alternate names:
- OP1
- osteogenic protein 1
Gene sequence:NCBI_Gene: 12162
Protein sequence:
Mouse Bmp7 target molecular function (prediction)
Predicted to enable BMP receptor binding activity; cytokine activity; and heparin binding activity. Involved in several processes, including allantois development; animal organ development; and chordate embryonic development. Acts upstream of or within several processes, including embryonic morphogenesis; morphogenesis of a branching epithelium; and regulation of morphogenesis of a branching structure. Located in extracellular space. Is expressed in several structures, including alimentary system; embryo ectoderm; embryo mesenchyme; genitourinary system; and sensory organ. Used to study obstructive sleep apnea and osteoarthritis. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human BMP7 (bone morphogenetic protein 7).
Rat Bmp7 molecular target information
Molecular name: Bmp7, bone morphogenetic protein 7
Also known as:
- BMP-7
- bone moorphogenic protein-7
Gene sequence:NCBI_Gene: 85272
Protein sequence:UniProtKB: G3V6W8
Rat Bmp7 target molecular function (prediction)
Enables heparin binding activity. Involved in several processes, including response to estradiol; response to peptide hormone; and response to vitamin D. Located in collagen-containing extracellular matrix; extracellular space; and vesicle. Biomarker of acute kidney tubular necrosis; kidney disease; nephroblastoma; and pyelonephritis. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human BMP7 (bone morphogenetic protein 7).