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ACE2 molecular target information overview


  • Molecular name: ACE2, angiotensin converting enzyme 2
  • Alias: ACEH
  • Alias: peptidyl-dipeptidase A; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin I converting enzyme 2


    • Overview of ACE2 molecular targets


    Angiotensin-converting enzyme 2 (ACE-2), also known as ACEH (ACE homolog), is an indispensable membrane protein and zinc metalloproteinase of the ACE family. ACE2 is a key enzyme in the renin-angiotensin system that regulates blood pressure. ACE-2 cleaves angiotensin I and II as a carboxypeptidase. Specifically, ACE2 cleaves the terminal nonapeptide from angiotensin I or the terminal heptapeptide from angiotensin II to produce angiotensin, respectively. The resulting peptides resist the effects of angiotensin II and act as vasodilators. ACE-2 has been shown to be a functional receptor for the human coronaviruses SARS-CoV and SARS-CoV-2.


    Human ACE2 molecular target information


    Molecular name: ACE2, angiotensin converting enzyme 2


    Alias:

    • ACE-related carboxypeptidase
    • ACEH
    • angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
    • angiotensin I converting enzyme 2
    • angiotensin-converting enzyme 2
    • angiotensin-converting enzyme homolog
    • angiotensin-converting enzyme-related carboxypeptidase
    • DKFZp434A014
    • metalloprotease MPROT15
    • peptidyl-dipeptidase A
    • truncated angiotensin converting enzyme 2

    Gene sequence:NCBI_Gene: 59272

    Protein sequence:UniProtKB: Q9BYF1


    Human ACE2 target molecular function (prediction)


    Enables identical protein binding activity; peptidase activity; and virus receptor activity. Involved in several processes, including angiotensin-mediated drinking behavior; positive regulation of gap junction assembly; and regulation of transmembrane transport. Located in cell surface; extracellular space; and plasma membrane. Part of apical plasma membrane and brush border membrane. Implicated in several diseases, including avian influenza; cerebral malaria; hypertension (multiple); respiratory syncytial virus infectious disease; Biomarker of congestive heart failure; hypertrophic cardiomyopathy; and pancreatic ductal carcinoma.


    Mouse Ace2 molecular target information


    Molecular name:Ace2, angiotensin I converting enzyme (peptidyl-dipeptidase A) 2


    Alias:

    • 2010305L05Rik
    • RIKEN cDNA 2010305L05 gene


    Gene sequence:NCBI_Gene: 70008

    Protein sequence:


    Mouse Ace2 target molecular function (prediction)


    Predicted to enable identical protein binding activity; peptidase activity; and virus receptor activity. Involved in positive regulation of cardiac muscle contraction and tryptophan transport. Located in brush border membrane and cytoplasm. Is expressed in several structures, including brain; cardiovascular system; extraembryonic component; genitourinary system; and respiratory system. Used to study COVID-19 and congestive heart failure. Human ortholog(s) of this gene implicated in several diseases, including avian influenza; cerebral malaria; hypertension (multiple); respiratory syncytial virus infectious disease; and severe acute respiratory syndrome. Orthologous to human ACE2 (angiotensin converting enzyme 2).


    Rat Ace2 molecular target information


    Molecular name: Ace2, angiotensin I converting enzyme 2

    Alias:

    • ACE-related carboxypeptidase
    • angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
    • angiotensin-converting enzyme 2
    • anigotensin-converting enzyme-related carboxypeptidase
    • renal angiotensin-converting enzyme 2

    Gene sequence:NCBI_Gene: 302668

    Protein sequence:


    Rat Ace2 target molecular function (prediction)


    Enables carboxypeptidase activity. Involved in maternal process involved in female pregnancy; negative regulation of ERK1 and ERK2 cascade; and negative regulation of smooth muscle cell proliferation. Located in extracellular space and membrane. Used to study glaucoma; myocardial infarction; and thrombosis. Biomarker of hypertension; lung disease; middle cerebral artery infarction; myocardial infarction; and primary biliary cholangitis. Human ortholog(s) of This gene implicated in several diseases, including avian influenza; cerebral malaria; hypertension (multiple); respiratory syncytial virus infectious disease; and severe acute respiratory syndrome. Orthologous to human ACE2 (angiotensin converting enzyme 2).