EGF molecular target information overview
Review of EGF molecular targets
Epidermal growth factor (EGF) is a growth factor that stimulates cell growth, proliferation and differentiation by binding to its receptor EGFR. EGF is a small molecular weight polypeptide that was first purified from the mouse submandibular gland and subsequently found in many human tissues, including the submandibular gland and parotid gland. Salivary EGF, regulated by inorganic iodine in the diet, plays an important physiological role in maintaining the health of the esophagus and stomach tissue. The physiological effects of salivary EGF include healing oral and gastric ulcers, inhibiting gastric acid secretion, stimulating DNA synthesis, and protecting the mucosa from intraluminal harmful factors (such as gastric acid, bile acid, pepsin and trypsin) and physical, chemical and bacterial factors. Enhanced EGF receptor activity can be observed in certain cancers that are usually associated with receptor mutations and dysfunction (such as constitutive receptor signaling that is independent of EGF levels or binding to EGF).
Human EGF molecular target information
Molecular name: EGF, epidermal growth factor
Alias:
- beta-urogastrone
- HOMG4
- pro-epidermal growth factor
- URG
Gene sequence:NCBI_Gene: 1950
Protein sequence:UniProtKB: P01133
Human EGF target molecular function (prediction)
Acts upstream of or within positive regulation of cell population proliferation. Located in extracellular exosome. Implicated in several diseases, including Zollinger-Ellison syndrome; hepatobiliary system cancer (multiple); high grade glioma (multiple); lung non-small cell carcinoma (multiple); and primary hypomagnesemia (multiple). Biomarker of several diseases, including acute kidney failure; lupus nephritis; neurodegenerative disease (multiple); pancreatic cancer (multiple); and pancreatitis.
Mouse Egf molecular target information
Molecular name: Egf, epidermal growth factor
Alias:
- AI790464
- expressed sequence AI790464
Gene sequence:NCBI_Gene: 13645
Protein sequence:
- UniprotKB: P01132
- UniprotKB: A0A0G2JDT8
- UniprotKB: A0A0G2JF92
- UniprotKB: A0A0G2JFB8
- UniprotKB: Q3UWD7
- UniprotKB: Q8VD07
Mouse Egf target molecular function (prediction)
Enables epidermal growth factor receptor binding activity. Involved in several processes, including negative regulation of cholesterol efflux; positive regulation of ubiquitin-dependent protein catabolic process; and regulation of receptor signaling pathway via JAK-STAT. Acts upstream of or within several processes, including mammary gland alveolus development; positive regulation of cerebellar granule cell precursor proliferation; and positive regulation of protein tyrosine kinase activity. Located in extracellular space and plasma membrane. Is expressed in several structures, including 1st branchial arch; alimentary system; brain; genitourinary system; and liver and biliary system. Human ortholog(s) of this gene implicated in several diseases, including Zollinger-Ellison syndrome; hepatobiliary system cancer (multiple); high grade glioma (multiple); lung non-small cell carcinoma (multiple); and primary hypomagnesemia (multiple). Orthologous to human EGF (epidermal growth) factor).
Rat Egf molecular target information
Molecular name: Egf, epidermal growth factor
Alias:
- LOC103691699
- pro-epidermal growth factor
- uncharacterized LOC103691699
Gene sequence:NCBI_Gene: 25313
Protein sequence:
- UniprotKB: A0A0G2K4M4
- UniprotKB: A0A0G2K7A3
- UniprotKB: A0A0G2KAF5
- UniprotKB: J9SG97
- UniprotKB: P07522
Rat Egf target molecular function (prediction)
Enables epidermal growth factor receptor binding activity. Involved in several processes, including positive regulation of DNA biosynthetic process; positive regulation of ERK1 and ERK2 cascade; and positive of fibroblast proliferation. Acts upstream of or within regulation of protein transport. Located regulation in extracellular space. Used to study perinatal necrotizing enterocolitis. Biomarker of acute kidney failure. Human ortholog(s) of this gene implicated in several diseases, including Zollinger-Ellison syndrome; hepatobiliary system cancer (multiple); high grade glioma (multiple); lung non-small cell carcinoma (multiple); and primary hypomagnesemia (multiple). Orthologous to human EGF (epidermal growth factor).