IL1RN molecular target information overview
Overview of IL1RN molecular targets
Interleukin-1 receptor antagonist (IL-1ra, also known as IL-1F3) is a member of the IL-1 cytokine family that includes IL-1α and IL-1β. IL-1ra inhibits the activity of interleukin-1 by binding to the IL-1R1 receptor and preventing it from binding to the signaling coreceptor IL-1RAP. Mouse interleukin-1 receptor antagonist (IL-1ra) is a 22-25 kDa glycoprotein produced by a variety of cell types. Cells known to secrete IL-1ra include dermal fibroblasts, vascular smooth muscle cells, intestinal columnar epithelial cells, chondrocytes, macrophages, non-keratinized stratified squamous epithelial cells, mast cells, neutrophils and monocytes, Sertoli cells, and hepatocytes. There are two type I transmembrane glycoprotein receptors for IL-1ra: the biologically active 80 kDa type I IL-1 receptor (IL-1 RI) and the inactive 65 kDa type II IL-1 receptor (IL-1 RII). IL-1ra blocks the proinflammatory effects of IL-1, including the release of prostaglandin E2 and IL-6 from endothelial cells, fever, thrombocytosis, production of acute phase proteins in the liver, and expansion and infiltration of neutrophils.
Human IL1RN Molecular Target Information
Molecular name: IL1RN, interleukin 1 receptor antagonist
Alias:
- DIRA
- ICIL-1RA
- IL-1ra
- IL-1ra3
- IL-1RN
- IL1 inhibitor
- IL1F3
- IL1RA
- IL1RN (IL1F3)
- interleukin-1 receptor antagonist protein
- intracellular IL-1 receptor antagonist type II
- intracellular interleukin-1 receptor antagonist (icIL-1ra)
- IRAP
- MGC10430
- MVCD4
- type II interleukin-1 receptor antagonist
Gene sequence:NCBI_Gene: 3557
Protein sequence: UniProtKB: P18510
Human IL1RN target molecular function (prediction)
Enables cytokine receptor binding activity. Involved in several processes, including acute-phase response; negative regulation of heterotypic cell-cell adhesion; and negative regulation of interleukin-1-mediated signaling pathway. Located in extracellular space. Implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); kidney failure (multiple); lung disease (multiple); and vascular disease (multiple). Biomarker of several diseases, including autoimmune disease (multiple); chronic kidney disease (multiple); glomerulonephritis (multiple); lung disease (multiple); and obesity (multiple).
Mouse Il1rn molecular target information
Molecular name: Il1rn, interleukin 1 receptor antagonist
Alias:
- F630041P17Rik
- IL-1ra
- RIKEN cDNA F630041P17 gene
Gene sequence:NCBI_Gene: 16181
Protein sequence:
- UniprotKB: P25085
- UniprotKB: A0A0A6YVU4
- UniprotKB: Q3TBV5
- UniprotKB: Q542C7
- UniprotKB: Q542W1
- UniprotKB: Q8CGA1
Mouse Il1rn target molecular function (prediction)
Predicted to enable cytokine receptor binding activity. Acts upstream of or within insulin secretion and lipid metabolic process. Located in extracellular region and vesicle. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); kidney failure (multiple); lung disease (multiple); and vascular disease (multiple). Orthologous to human IL1RN (interleukin 1 receptor antagonist).
Rat Il1rn molecular target information
Molecular name: Il1rn, interleukin 1 receptor antagonist
Alias:
- IL-1ra
- IL-1RN
- IL1 inhibitor
- interleukin 1 receptor antagonist gene
- interleukin-1 receptor antagonist protein
- IRAP
Gene sequence:NCBI_Gene: 60582
Protein sequence:
Rat Il1rn target molecular function (prediction)
Enables interleukin-1 receptor binding activity. Involved in several processes, including cellular response to norepinephrine stimulus; chronic inflammatory response to antigenic stimulus; and fever generation. Located in extracellular space. Used to study adult respiratory distress syndrome; anti-basement membrane glomerulonephritis; hypertension; silicosis; (multiple); eye disease (multiple); kidney failure (multiple); lung disease (multiple); and vascular disease (multiple). Orthologous to human IL1RN (interleukin 1 receptor antagonist).