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SPP1 molecular target information overview


  • Molecular name: SPP1, secreted phosphoprotein 1
  • Gene family: Receptor ligands; SIBLING family
  • Alias: BSPI; ETA-1
  • Former name: BNSP; OPN
  • Alias: early T-lymphocyte activation 1; osteopontin; bone sialoprotein I


    • Overview of SPP1 molecular targets


    Osteopontin (OPN), also known as BSP-1, ETA-1, SPP-1 or Ric, is encoded by the SPP1 gene in humans and is mainly expressed in bones. The regulatory mechanism of the OPN gene has not been fully elucidated, and the regulatory mechanism is different in different cell types. OPN plays a role in biomineralization, bone remodeling, immune function, chemotaxis, cell activation and apoptosis, and is also associated with increased cardiomyocyte apoptosis and myocardial dysfunction. OPN is associated with many physiological and pathological processes including wound healing, bone turnover, tumorigenesis, inflammation, ischemia and immune response. Regulating plasma (or local) OPN levels is helpful in the treatment of autoimmune diseases, cancer metastasis, bone and tooth mineralization, osteoporosis and some forms of stress.


    Human SPP1 Molecular Target Information


    Molecular name: SPP1, secreted phosphoprotein 1


    Alias:

    • BNSP
    • bone sialoprotein 1
    • bone sialoprotein I
    • BSPI
    • early T-lymphocyte activation 1
    • ETA-1
    • MGC110940
    • nephropontin
    • OPN
    • osteopontin
    • osteopontin-C
    • osteopontin-D
    • osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein
    • secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)
    • secreted phosphoprotein 1 variant 6
    • secretted phosphoprotein-1 (osteopontin, bone sialoprotein)
    • SPP-1
    • SPP1/CALPHA1 fusion
    • urinary stone protein
    • uropontin

    Gene sequence:NCBI_Gene: 6696

    Protein sequence:UniProtKB: P10451


    Human SPP1 target molecular function (prediction)


    Enables integrin binding activity. Involved in several processes, including androgen catabolic process; cellular response to testosterone stimulus; and positive regulation of estradiol secretion. Located in Golgi apparatus and extracellular space. Implicated in several diseases, including autoimmune disease (multiple); biliary atresia; coronary artery disease (multiple); disease of cellular proliferation (multiple); and hepatitis. osseous heteroplasia; and urinary bladder cancer.


    Mouse Spp1 molecular target information


    Molecular name: Spp1, secreted phosphoprotein 1


    Alternate names:

    • 2ar
    • 44kDa bone phosphoprotein
    • AA960535
    • activation protein lymphocyte 1
    • AI790405
    • Apl-1
    • BNSP
    • bone sialoprotein 1
    • early T lymphocyte activation
    • Eta
    • ETA-1
    • expressed sequence AA960535
    • expressed sequence AI790405
    • minopontin
    • OP
    • Opn
    • Opnl
    • osteopontin
    • osteopontin-like protein
    • Ric
    • rickettsia tsutsugamushi resistance
    • Spp-1


    Gene sequence:NCBI_Gene: 20750

    Protein sequence:


    Mouse Spp1 target molecular function (prediction)


    Enables extracellular matrix binding activity. Acts upstream of or within several processes, including cellular ion homeostasis; cellular response to leukemia inhibitory factor; and neutrophil chemotaxis. Located in apical part of cell and cytoplasm. Is expressed in several structures, including alimentary system; brain; metanephros; reproductive system; and skeleton. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; coronary artery disease (multiple); disease of cellular proliferation (multiple); and hepatitis. Orthologous to human SPP1 (secreted phosphoprotein 1).


    Rat Spp1 molecular target information


    Molecular name: Spp1, secreted phosphoprotein 1

    Alias:

    • bone sialoprotein 1
    • LOC100359743
    • OSP
    • osteopontin
    • osteopontin-like
    • Sialoprotein (osteopontin)
    • SPP-1

    Gene sequence:NCBI_Gene: 25353

    Protein sequence:UniProtKB: P08721


    Rat Spp1 target molecular function (prediction)


    Predicted to enable extracellular matrix binding activity and integrin binding activity. Involved in several processes, including negative regulation of collateral sprouting of intact axon in response to injury; osteoblast differentiation; and positive regulation of bone resorption. Located in several cellular components, including extracellular space; perinuclear region of cytoplasm; and vesicle. Used to study several diseases, including encephalomyelitis; myocarditis; radiculopathy; renovascular hypertension; and visual epilepsy. Biomarker of autosomal dominant polycystic kidney disease; calcinosis; and glomerulosclerosis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; coronary artery disease (multiple); disease of cellular proliferation (multiple); and hepatitis. Orthologous to human SPP1 (secreted phosphoprotein 1).