IL33 molecular target information overview
Overview of IL33 molecular targets
Interleukin 33 (IL-33), also known as NF-HEV and DVS27, is a member of the IL-1 family with a molecular weight of 30 kDa. It is secreted by many types of cells, including fibroblasts, mast cells, dendritic cells, macrophages, osteoblasts, endothelial cells, and epithelial cells. IL-33 can induce helper T cells, mast cells, eosinophils, and basophils to secrete type II cytokines. IL-33 mediates its biological functions by binding to receptors ST2 and IL-1 receptor accessory protein (IL1RAP), activating extracellular molecules in the NF-κB and MAP kinase signaling pathways that can cause polarized Th2 cells to secrete type II cytokines (such as IL-5 and IL-13). After injection, IL-33 can induce type II cytokines in vivo, which is believed to induce severe pathological changes in mucosal organs.
Human IL33 Molecular Target Information
Molecular name: IL33, interleukin 33
Alias:
- C9orf26
- DKFZp586H0523
- DVS27
- DVS27-related protein
- IL-1F11
- IL-33
- IL1F11
- interleukin-1 family member 11
- interleukin-33
- NF-HEV
- NFEHEV
- nuclear factor for high endothelial venules
- nuclear factor from high endothelial venules
- RP11-575C20.2
Gene sequence:NCBI_Gene: 90865
Protein sequence:UniProtKB: O95760
Human IL33 target molecular function (prediction)
Enables cytokine activity. Involved in negative regulation of transcription by RNA polymerase II; positive regulation of chemokine production; and positive regulation of macrophage activation. Located in nucleoplasm. Part of cytoplasm and nucleus. Implicated in candidiasis; inflammatory bowel disease; and peptic ulcer disease. Biomarker of several diseases, including colitis (multiple); common cold; gout; liver disease (multiple);
Mouse Il33 molecular target information
Molecular name: Il33, interleukin 33
Alias:
- 9230117N10Rik
- Il-33
- Il1f11
- NF-HEV
- RIKEN cDNA 9230117N10 gene
Gene sequence:NCBI_Gene: 77125
Protein sequence:
Mouse Il33 target molecular function (prediction)
Acts upstream of or within several processes, including negative regulation of macrophage proliferation; positive regulation of cellular defense response; and positive regulation of macromolecule metabolic process. Located in nucleus. Is expressed in several structures, including adrenal gland; alimentary system; genitourinary system; nervous system; and sensory organ. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in candidiasis; inflammatory bowel disease; and peptic ulcer disease. Orthologous to human IL33 (interleukin 33).
Rat Il33 molecular target information
Molecular name: Il33, interleukin 33
Alias:
- IL-33
- interleukin-33
- LOC361749
- RGD1311155
- similar to RIKEN cDNA 9230117N10
Gene sequence:NCBI_Gene: 361749
Protein sequence:
Rat Il33 target molecular function (prediction)
Predicted to enable cytokine activity and interleukin-33 receptor binding activity. Involved in several processes, including cellular response to mechanical stimulus; positive regulation of oligodendrocyte differentiation; and regulation of sensory perception of pain. Located in nucleus. Biomarker of acute myocardial infarction; colon cancer; and diabetes mellitus. Human ortholog(s) of this gene implicated in candidiasis; inflammatory bowel disease; and peptic ulcer disease. Orthologous to human IL33 (interleukin 33).