Blog

CD274 Molecular Target Information Overview


  • Molecular name:CD274, CD274 molecule
  • Gene family:CD molecules; Receptor ligands; V-set domain containing; C2-set domain containing; B7 family
  • Alias:B7-H;
  • Former name: PDCD1LG1
  • Alias: B7 homolog 1; programmed cell death 1 ligand 1; CD274 antigen


    • CD274 molecular target review


    Programmed death ligand 1 (PD-L1), also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1), is a type I transmembrane protein with a molecular weight of 40 kDa encoded by the CD274 gene. PD-L1 may play an important role in the suppression of the immune system in pregnancy, tissue transplantation, autoimmune diseases, and other diseases such as hepatitis. Normally, the immune system responds to foreign antigens that accumulate in lymph nodes or spleen, triggering the proliferation of antigen-specific CD8+ T cells. PD-1 receptor/PD-L1 or B7.1 receptor/PD-L1 binding transmits inhibitory signals, thereby inhibiting the proliferation of CD8+ T cells. In contrast, there are reports that PD-L1 has a co-stimulatory effect on dormant T cells. PD-L1 may inhibit the sustained response of T cells by inducing apoptosis of T cells and blocking cell cycle progression.


    Human CD274 Molecular Target Information


    Molecular name: CD274, CD274 molecule


    Alias:

    • B7 homolog 1
    • B7-H
    • B7H1
    • CD274 antigen
    • hPD-L1
    • MGC142294
    • MGC142296
    • PD-L1
    • PDCD1 ligand 1
    • PDCD1L1
    • PDCD1LG1
    • PDL1
    • programmed cell death 1 ligand 1
    • programmed death ligand 1

    Gene sequence:NCBI_Gene: 29126

    Protein sequence:UniProtKB: Q9NZQ7


    Human CD274 target molecule function (prediction)


    Involved in several processes, including positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process; regulation of T cell activation; and regulation of cytokine production. Located in several cellular components, including endosome membrane; extracellular exosome; and nucleoplasm. Biomarker of several diseases, including Cryptococcal meningitis; Human papillomavirus infectious disease; gastrointestinal system cancer (multiple); lymphoma (multiple); and tuberculosis (multiple).


    Mouse Cd274 molecular target information


    Molecular name: Cd274, CD274 antigen


    Alias:

    • B7-H1
    • PD-L1
    • Pdcd1lg1
    • programmed cell death 1 ligand 1


    Gene sequence:NCBI_Gene: 60533

    Protein sequence:


    Mouse Mouse Cd274 Target Molecular Function (Prediction)


    Acts upstream of or within negative regulation of T cell proliferation and toxin transport. Located in external side of plasma membrane. Is expressed in retina and thymus primordium. Orthologous to human CD274 (CD274 molecule).


    Rat Cd274 molecular target information


    Molecular name: Cd274, CD274 molecule

    Alias:

    • CD274 antigen
    • LOC499342
    • Pdcd1lg1
    • programmed cell death 1 ligand 1
    • RGD1566211
    • similar to PD-1-ligand precursor

    Gene sequence:NCBI_Gene: 499342

    Protein sequence:UniProtKB: D4AE25


    Rat Cd274 target molecular function (prediction)


    Involved in positive regulation of T cell proliferation and positive regulation of cell migration. Located in cell surface. Biomarker of periodontitis and pre-eclampsia. Orthologous to human CD274 (CD274 molecule).