EPHB6 molecular target information overview
Overview of EPHB6 molecular targets
Ephrins can be divided into ephrin-A (EFNA) and ephrin-B (EFNB) classes based on structural and sequence relationships. Ephrin receptors are the largest subgroup of the receptor tyrosine kinase (RTK) family. Ephrin type B receptor 6 (EphB6) is an unusual Eph receptor that lacks catalytic ability due to changes in its kinase domain. EphB6 can positively and negatively regulate cell adhesion and migration. In addition, Ephrin-B2 may be a physiological ligand for the EphB6 receptor. In some tumor types, including breast cancer, increased metastatic activity is associated with decreased expression of the EphB6 receptor, suggesting that EphB6 may act as a suppressor of cancer invasion. EphB6 inhibits cancer invasion through c-Cbl-dependent signaling, morphological changes, and cell attachment, suggesting that EphB6 may be a useful prognostic marker and therapeutic target.
Human EPHB6 Molecular Target Information
Molecular name: EPHB6, EPH receptor B6
Alias:
- ephrin type-B receptor 6
- HEP
- human kinase-defective Eph-family receptor protein
- MGC129910
- MGC129911
- tyrosine-protein kinase-defective receptor EPH-6
Gene sequence:NCBI_Gene: 2051
Protein sequence: UniProtKB: O15197
Human EPHB6 target molecular function (prediction)
Predicted to enable transmembrane-ephrin receptor activity. Predicted to be involved in axonogenesis; positive regulation of kinase activity; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within several processes, including activated T cell proliferation; positive regulation of T cell costimulation; and type IV hypersensitivity. Predicted to be located in cytosol; extracellular region; and plasma membrane. Predicted to be part of receptor complex. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane.
Mouse Ephb6 molecular target information
Molecular name: Ephb6, Eph receptor B6
Alias:
- Cekl
- chicken eph/elk receptor-like protein
- Mep
Gene sequence:NCBI_Gene: 13848
Protein sequence:
Mouse Ephb6 target molecular function (prediction)
Predicted to enable transmembrane-ephrin receptor activity. Acts upstream of or within several processes, including activated T cell proliferation; positive regulation of T cell costimulation; and type IV hypersensitivity. Located in cell surface. Is expressed in several structures, including alimentary system; central nervous system; integumental system; intraembryonic coelom; and sensory organ. Orthologous to human EPHB6 (EPH receptor B6).
Rat Ephb6 molecular target information
Molecular name: Ephb6, Eph receptor B6
Alias:
- ephrin type-B receptor 6
- LOC102554290
- LOC312275
- serine/arginine repetitive matrix protein 2-like
- tyrosine-protein kinase-defective receptor EPH-6
Gene sequence:NCBI_Gene: 312275
Protein sequence:UniProtKB: P0C0K7
Rat Ephb6 target molecular function (prediction)
Predicted to enable transmembrane-ephrin receptor activity. Predicted to be involved in axonogenesis; positive regulation of kinase activity; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within several processes, including activated T cell proliferation; positive regulation of T cell costimulation; and type IV hypersensitivity. Predicted to be located in cell surface. Predicted to be part of receptor complex. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane. Orthologous to human EPHB6 (EPH receptor B6).