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Overview of MICB molecular target information


  • Molecular name: MICB, MHC class I polypeptide-related sequence B
  • Gene family: C1-set domain containing
  • Alias: PERB11.2


    • Overview of MICB molecular targets


    MICB (human histocompatibility complex class I-related gene B) is a transmembrane glycoprotein that is a ligand for the human NKG2D type II receptor. The MICB gene is located in the MHC-I class region of human chromosome 6 and is polymorphic, with more than 15 known human alleles. MICB is only expressed in trace amounts in normal cells, but it is usually expressed in epithelial tumors and can be induced by bacterial and viral infections. Therefore, the identification of MICB is closely related to tumor monitoring, viral infection, and the prevention of autoimmune diseases.


    Human MICB molecular target information


    Molecular name: MICB, MHC class I polypeptide-related sequence B


    Alias:

    • MHC class I antigen-related protein B
    • MHC class I chain-related protein B
    • MHC class I mic-B antigen
    • MHC class I-like molecule PERB11.2-IMX
    • MIC-B
    • PERB11.2
    • stress inducible class I homolog

    Gene sequence:NCBI_Gene: 4277

    Protein sequence:UniProtKB: Q29980


    Human MICB target molecular function (prediction)


    Enables natural killer cell lectin-like receptor binding activity. Involved in several processes, including immune response-activating cell surface receptor signaling pathway; negative regulation of defense response to virus by host; and response to retinoic acid. Predicted to be located in cell surface. Predicted to be anchored component of external side of plasma membrane. Predicted to be active in external side of plasma membrane and extracellular space.


    Mouse Mill2 molecular target information


    Molecular name: Mill2, MHC I like leukocyte 2


    Alias:

    • None


    Gene sequence:NCBI_Gene: 243864

    Protein sequence:


    Mouse Mill2 target molecular function (prediction)


    Predicted to enable natural killer cell lectin-like receptor binding activity. Predicted to be involved in immune response. Is anchored component of external side of plasma membrane. Orthologous to human MICA (MHC class I polypeptide-related sequence A) and MICB (MHC class I polypeptide-related sequence B).


    Rat Micb molecular target information


    Molecular name: Micb, MHC class I polypeptide-related sequence B

    Alias:

    • MHC class I-like located near the leukocyte receptor complex 2
    • MHC class I-like located near the LRC, 2
    • MHC class I-like protein MILL2
    • MHC I like leukocyte 2
    • Mill2
    • Mill2 gene for MHC class I-like located near the LRC, 2, exon 3, partial cds, strain:LEW.1lm1

    Gene sequence:NCBI_Gene: 365212

    Protein sequence:


    Rat Micb target molecular function (prediction)


    Predicted to enable natural killer cell lectin-like receptor binding activity. Predicted to be involved in several processes, including immune response-activating cell surface receptor signaling pathway; negative regulation of defense response to virus by host; and response to retinoic acid. Predicted to be anchored component of membrane. Predicted to be active in external side of plasma membrane and extracellular space. Orthologous to human MICB (MHC class I polypeptide-related sequence B).