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DCN molecular target information overview


  • Molecular name: DCN, decorin
  • Gene family: Small leucine rich repeat proteoglycans
  • Alias: DSPG2; SLRR1B
  • Alias: decorin proteoglycan


    • Overview of DCN molecular targets


    Decorin (decorin) is a secreted proteoglycan of the leucine-rich low molecular weight proteoglycan (SLRP) family. Decorin regulates the biological activity of the extracellular collagen matrix and matrix-associated growth factors FGF, GDF-8/Myostatin, TGF-beta, and WISP-1. It also binds to and activates EGF receptors, ErbB4, and IGF-1 receptors. Decorin promotes myoblast differentiation, supports angiogenesis, and inhibits tumor development. Studies have shown that Decorin may have an inhibitory effect on the contracture of hypertrophic scars, indicating that it has a certain role in preventing hypertrophic scar formation and promoting scar maturation.


    Human DCN Molecular Target Information


    Molecular name: DCN, decorin


    Alias:

    • bone proteoglycan II
    • CSCD
    • decorin proteoglycan
    • dermatan sulphate proteoglycans II
    • DSPG2
    • PG-S2
    • PG40
    • PGII
    • PGS2
    • proteoglycan core protein
    • SLRR1B
    • small leucine-rich protein 1B

    Gene sequence:NCBI_Gene: 1634

    Protein sequence:UniProtKB: P07585


    Human DCN target molecular function (prediction)


    Enables RNA binding activity. Involved in positive regulation of autophagy. Acts upstream of or within several processes, including positive regulation of mitochondrial depolarization; positive regulation of mitochondrial fission; and of signal transduction. Located in extracellular space. Colocalizes with collagen-containing regulation extracellular matrix. Implicated in breast carcinoma; congenital stromal corneal dystrophy; and high grade glioma. Biomarker of gestational diabetes and type 2 diabetes mellitus.


    Mouse Dcn molecular target information


    Molecular name: Dcn, decorin


    Alias:

    • DC
    • SLRR1B


    Gene sequence:NCBI_Gene: 13179

    Protein sequence:


    Mouse Dcn target molecular function (prediction)


    Enables extracellular matrix binding activity and glycosaminoglycan binding activity. Acts upstream of or within peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan. Located in collagen-containing extracellular matrix. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Used to study Ehlers-Danlos syndrome and congenital stromal corneal dystrophy. Human ortholog(s) of this gene implicated in breast carcinoma; congenital stromal corneal dystrophy; and high grade glioma. Orthologous to human DCN (decorin).


    Rat Dcn molecular target information


    Molecular name: Dcn, decorin

    Alias:

    • bone proteoglycan II
    • dermatan sulfate proteoglycan-II (decorin)
    • DSPG
    • MGC94682
    • PG-S2
    • PG40

    Gene sequence:NCBI_Gene: 29139

    Protein sequence:UniProtKB: Q01129


    Rat Dcn target molecular function (prediction)


    Enables collagen binding activity and protein N-terminus binding activity. Involved in several processes, including animal organ development; response to lipopolysaccharide; and wound healing. Located in extracellular matrix. Part of collagen type VI trimer. Biomarker of asthma; myocardial infarction; and obesity. Human ortholog(s) of this gene implicated in breast carcinoma; congenital stromal corneal dystrophy; and high grade glioma. Orthologous to human DCN (decorin).