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FCGR3B molecular target information overview


  • Molecular name:FCGR3B, Fc gamma receptor IIIb
  • Gene family:CD molecules; Immunoglobulin like domain containing
  • Alias:CD16;
  • Alias:Fc fragment of IgG, low affinity IIIb, receptor for (CD16); Fc fragment of IgG, low affinity IIIb, receptor for (CD16b); Fc fragment of IgG receptor IIIb


    • Overview of FCGR3B molecular targets


    CD16 is a cell membrane protein with a glycosylated phosphatidylinositol anchor chain and a component of the low-affinity Fcγ receptor (FcγRIII). It includes two subtypes, CD16a and CD16b, which have slight structural differences. CD16 is expressed in NK cells (only in mature NK cells, not in NK precursors and immature NK cells), some T lymphocytes, neutrophils and macrophages.


    Human FCGR3B Molecular Target Information


    Molecular name: FCGR3B, Fc gamma receptor IIIb


    Alias:

    • CD16
    • CD16A
    • CD16b
    • Fc fragment of IgG, low affinity IIIb, receptor for (CD16b)
    • Fc fragment of IgG, low affinity IIIb, receptor for (CD16)
    • Fc gamma receptor III receptor-B
    • Fc gamma receptor IIIb
    • Fc-gamma receptor IIIb (CD 16)
    • fc-gamma RIII
    • fc-gamma RIII-beta
    • fc-gamma RIIIb
    • FCG3
    • FCGR3
    • FCGR3A
    • FCR-10
    • FCRIII
    • FCRIIIb
    • igG Fc receptor III-1
    • low affinity immunoglobulin gamma Fc region receptor III-B

    Gene sequence:NCBI_Gene: 2215

    Protein sequence:UniProtKB: O75015


    Human FCGR3B target molecular function (prediction)


    Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in cell surface receptor signaling pathway and regulation of immune response. Located in extracellular exosome.


    Mouse Fcgr4 molecular target information


    Molecular name:Fcgr4, Fc receptor, IgG, low affinity IV


    Alias:

    • 4833442P21Rik
    • CD16-2
    • Fc fragment of IgG, low affinity IIIa, receptor
    • FcgammaRIV
    • Fcgr3a
    • RIKEN cDNA 4833442P21 gene


    Gene sequence:NCBI_Gene: 246256

    Protein sequence:


    Mouse Fcgr4 target molecular function (prediction)


    Enables IgE receptor activity and IgG receptor activity. Involved in neutrophil activation and positive regulation of bone resorption. Located in cell surface. Is expressed in liver. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); (Fc fragment of IgG receptor IIIa) and FCGR3B (Fc fragment of IgG receptor IIIb).


    Rat Fcgr3a molecular target information


    Molecular name:Fcgr3a, Fc fragment of IgG receptor IIIa

    Alias:

    • Fc fragment of IgG intermediate affinity IV receptor
    • Fc fragment of IgG, low affinity IIIa, receptor
    • Fc fragment of IgG, low affinity IIIa, receptor for (CD16)
    • Fcgr4
    • LOC304966
    • transmembrane receptor FcgammaRIII-X

    Gene sequence:NCBI_Gene: 304966

    Protein sequence:


    Rat Fcgr3a target molecular function (prediction)


    Predicted to enable IgE receptor activity and IgG receptor activity. Involved in cellular response to lipopolysaccharide; regulation of sensory perception of pain; and wound healing. Located in cell surface. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); autoimmune disease (multiple); glomerulonephritis (multiple); hematologic cancer (multiple); and immunodeficiency 20. genes including FCGR3A (Fc fragment of IgG receptor IIIa).