Blog

IGFBP3 molecular target information overview


  • Molecular name: IGFBP3, insulin like growth factor binding protein 3
  • Gene family: Insulin like growth factor binding proteins
  • Alias: IBP3; BP-53
  • Alias: growth hormone-dependent binding protein; acid stable subunit of the 140 K IGF complex; binding protein 53; binding protein 29; IGF-binding protein 3; insulin-like growth factor binding protein 3


    • IGFBP3 molecular targets review


    Insulin-like growth factor binding protein 3 (IGFBP-3), encoded by the IGFBP3 gene in humans. IGFBP-3 is one of six IGF binding proteins (IGFBP-1 to 6) that have a highly conserved structure and bind to IGF-1 and IGF-2 with high affinity. IGFBP-3 is the major transporter of IGF in the blood. It interacts with cell surface proteins to affect cell signaling after extracellular or internalization, and it can also enter the cell nucleus, where it binds nuclear hormone receptors and other ligands. Based on cell growth experiments, animal cancer models and epidemiological studies, IGFBP-3 appears to act as a tumor suppressor gene with low penetrance. Dysregulated IGFBP-3 is involved in many cancers. Serum IGFBP-3 levels can be used to screen for growth hormone deficiency. IGFBP-3 levels are decreased in the serum of patients with AIDS, uncontrolled diabetes, trauma and severe burns.


    Human IGFBP3 molecular target information


    Molecular name:IGFBP3, insulin like growth factor binding protein 3


    Alias:

    • acid stable subunit of the 140 K IGF complex
    • binding protein 29
    • binding protein 53
    • BP-53
    • growth hormone-dependent binding protein
    • IBP-3
    • IBP3
    • IGF-binding protein 3
    • IGFBP-3
    • insulin-like growth factor binding protein 3
    • insulin-like growth factor-binding protein 3

    Gene sequence:NCBI_Gene: 3486

    Protein sequence:UniProtKB: P17936


    Human IGFBP3 target molecular function (prediction)


    Enables insulin-like growth factor I binding activity and protein tyrosine phosphatase activator activity. Involved in several processes, including negative regulation of smooth muscle cell migration; negative regulation of smooth muscle cell proliferation; and positive regulation of myoblast differentiation. Acts upstream of or within negative regulation of cell population proliferation; negative regulation of protein phosphorylation; and protein phosphorylation. Located in extracellular space and nucleus. Part of insulin-like growth factor ternary complex. Implicated in several diseases, including Alzheimer's disease; Turner syndrome; diabetes mellitus (multiple); prostate cancer; and transitional cell carcinoma. Biomarker of several diseases, including Barrett's esophagus; Down syndrome; autoimmune disease (multiple); bone disease (multiple); and urinary system cancer (multiple).


    Mouse Igfbp3 molecular target information


    Molecular name:Igfbp3, insulin-like growth factor binding protein 3


    Alias:

    • AI649005
    • expressed sequence AI649005
    • IGFBP-3


    Gene sequence:NCBI_Gene: 16009

    Protein sequence:


    Mouse Igfbp3 target molecular function (prediction)


    Acts upstream of or within several processes, including osteoblast differentiation; positive regulation of signal transduction; and type B pancreatic cell proliferation. Located in extracellular space. Is expressed in several structures, including alimentary system; brain; early embryo; gonad; and limb. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Turner syndrome; diabetes mellitus (multiple); prostate cancer; and transitional cell carcinoma. Orthologous to human IGFBP3 (insulin like growth factor binding protein 3).


    Rat Igfbp3 molecular target information


    Molecular name:Igfbp3, insulin-like growth factor binding protein 3

    Alias:

    • IBP-3
    • IGF-binding protein 3
    • IGF-BP3
    • IGFBP-3
    • Insulin-like growth factor-binding protein (IGF-BP3)
    • insulin-like growth factor-binding protein 3
    • MGC156773

    Gene sequence:NCBI_Gene: 24484

    Protein sequence:


    Rat Igfbp3 target molecular function (prediction)


    Enables insulin-like growth factor II binding activity. Involved in several processes, including cellular response to Thyroglobulin triiodothyronine; cellular response to estradiol stimulus; and response to peptide hormone. Located in extracellular space; heterochromatin; and platelet alpha granule. Part of insulin-like growth factor binary complex and insulin-like growth factor ternary complex. Used to study impotence. Biomarker of congenital diaphragmatic hernia; obesity. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Turner syndrome; diabetes mellitus (multiple); prostate cancer; and transitional cell carcinoma. Orthologous to human IGFBP3 (insulin like growth factor binding protein 3).