Blog

MKI67 molecular target information overview


  • Molecular name: MKI67, marker of proliferation Ki-67
  • Gene family: Protein phosphatase 1 regulatory subunits
  • Alias: MIB-1; PPP1R105; Ki-67
  • Alias: protein phosphatase 1, regulatory subunit 105; Molecular Immunology Borstel antibody 1; antigen identified by monoclonal antibody Ki-67


    • Overview of MKI67 molecular targets


    KI-67, also known as Ki-67 or MKI67, is a protein encoded by the MKI67 gene in humans. Ki-67 is a 350-400 kDa nuclear protein that belongs to the member of the chromosome mitosis-associated proteins. In addition, Ki-67 is associated with ribosomal RNA transcription, and its inactivation inhibits ribosomal RNA synthesis. Ki-67 interacts with Hklp2 of 160 kDa, which promotes centrosome separation and spindle polarity. It also directly interacts with NIFK and binds UBF, thereby playing a role in the synthesis of ribosomal RNA. In patients with ER-positive breast cancer, Ki-67 represents a group of highly proliferative subgroups, which make them benefit more from adjuvant chemotherapy.


    Human MKI67 Molecular Target Information


    Molecular name: MKI67, marker of proliferation Ki-67


    Alias:

    • antigen identified by monoclonal antibody Ki-67
    • antigen KI-67
    • antigen Ki67
    • KIA
    • MIB-
    • MIB-1
    • Molecular Immunology Borstel antibody 1
    • PPP1R105
    • proliferation marker protein Ki-67
    • proliferation-related Ki-67 antigen

    Gene sequence:NCBI_Gene: 4288

    Protein sequence: UniProtKB: P46013


    Human MKI67 target molecular function (prediction)


    Enables protein C-terminus binding activity. Involved in regulation of chromosome segregation and regulation of mitotic nuclear division. Located in chromosome; nuclear body; and nucleolus. Colocalizes with condensed chromosome. Implicated in Crohn's disease; breast cancer; human immunodeficiency virus infectious disease; endocrine gland cancer (multiple); gastrointestinal system cancer (multiple); and interstitial cystitis.


    Mouse Mki67 molecular target information


    Molecular name:Mki67, antigen identified by monoclonal antibody Ki 67


    Alias:

    • D630048A14Rik
    • Ki-67
    • Ki67
    • RIKEN cDNA D630048A14 gene


    Gene sequence:NCBI_Gene: 17345

    Protein sequence:


    Mouse Mki67 target molecular function (prediction)


    Predicted to enable protein C-terminus binding activity. Involved in regulation of chromatin organization. Acts upstream of or within cholangiocyte proliferation; hepatocyte proliferation; and meiotic cell cycle. Located in chromosome; cytoplasm; and nucleolus. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skin. Human ortholog(s) of this gene implicated in Crohn's disease; breast cancer; human immunodeficiency virus infectious disease; and pancreatic cancer. Orthologous to human MKI67 (marker of proliferation Ki-67).


    Rat Mki67 molecular target information


    Molecular name: Mki67, marker of proliferation Ki-67

    Alias:

    • antigen identified by monoclonal antibody Ki-67
    • antigen KI-67
    • LOC291234
    • proliferation marker protein Ki-67

    Gene sequence:NCBI_Gene: 291234

    Protein sequence:UniProtKB: D4A0Y6


    Rat Mki67 target molecular function (prediction)


    Predicted to enable protein C-terminus binding activity. Involved in several processes, including DNA metabolic process; animal organ regeneration; and cellular response to heat. Located in nucleus. Used to study high grade glioma; leiomyoma; and prostate carcinoma. Biomarker of colon cancer; kidney disease; mucositis; type 2 diabetes mellitus; immunodeficiency virus infectious disease; and pancreatic cancer. Orthologous to human MKI67 (marker of proliferation Ki-67).