Overview of IL4 molecular target information
Overview of IL4 molecular targets
IL-4 is a cytokine secreted by type II helper T cells (Th2 cells). IL-4 is a pleiotropic cytokine that plays an important role in regulating the proliferation, differentiation, and apoptosis of T, B lymphocytes and other types of cells, and in promoting immune responses characterized by Th2 cells. The multiple biological effects of IL-4 depend on cell type and differentiation state. Studies have shown that it has multiple roles in mediating immune responses to allergic diseases, autoimmune diseases, infectious diseases, tumors, and other diseases, and has therapeutic effects on tumors, autoimmune diseases, infectious diseases, and other diseases. IL-4 also has a regulatory effect on vaccine immune responses.
Human IL4 Molecular Target Information
Molecular name: IL4, interleukin 4
Alias:
- B cell growth factor 1
- B_cell stimulatory factor 1
- B-cell stimulatory factor 1
- BCGF-1
- BCGF1
- binetrakin
- BSF-1
- BSF1
- IL-4
- interleukin 4 variant 2
- interleukin-4
- lymphocyte stimulatory factor 1
- MGC79402
- pitrakinra
Gene sequence:NCBI_Gene: 3565
Protein sequence:UniProtKB: P05112
Human IL4 target molecular function (prediction)
Predicted to enable cytokine activity. Involved in several processes, including negative regulation of cellular response to transforming growth factor beta stimulus; negative regulation of complement-dependent cytotoxicity; and positive regulation of macromolecule metabolic process. Acts upstream of or within positive of cell migration and positive regulation of cell population proliferation. Predicted to be located in external side of plasma membrane. Predicted to be active in extracellular space. Implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); hepatitis B; hepatitis C; and pancreatic cancer (multiple). Biomarker of several diseases, including allergic rhinitis; alopecia universalis; anogenital venereal wart; autoimmune disease (multiple); and liver disease (multiple).
Mouse Il4 molecular target information
Molecular name: Il4, interleukin 4
Alias:
- Il-4
Gene sequence:NCBI_Gene: 16189
Protein sequence:
Mouse Il4 target molecular function (prediction)
Enables cytokine activity. Involved in several processes, including innate immune response in mucosa; negative regulation of white fat cell proliferation; and regulation of gene expression. Acts upstream of or within several processes, including T-helper cell differentiation; positive of macromolecule metabolic process; and regulation of leukocyte activation. Located in external side of plasma membrane and extracellular space. Is expressed in several structures, including brain; colon; hemolymphoid system; liver; and placenta. Used to study Sjogren's syndrome; atopic dermatitis; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); hepatitis B; hepatitis C; and pancreatic cancer (multiple). Orthologous to human IL4 (interleukin 4).
Rat Il4 molecular target information
Molecular name: Il4, interleukin 4
Alias:
- B-cell growth factor 1
- B-cell IGG differentiation factor
- B-cell stimulatory factor 1
- BSF-1
- IL-4
- Il4e12
- interleukin-4
- lymphocyte stimulatory factor 1
Gene sequence:NCBI_Gene: 287287
Protein sequence:
Rat Il4 target molecular function (prediction)
Predicted to enable cytokine activity. Involved in several processes, including positive regulation of biosynthetic process; positive regulation of leukocyte migration; and regulation of defense response. Located in extracellular space. Used to study anti-basement membrane glomerulonephritis; autoimmune thyroiditis; and pelvic inflammatory disease. Biomarker of several diseases, including cerebrovascular disease (multiple); interstitial lung disease (multiple); irritant dermatitis; primary biliary cholangitis; and rhinitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); hepatitis B; hepatitis C; and pancreatic cancer (multiple). Orthologous to human IL4 (interleukin 4).