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CD163 molecular target information overview


  • Molecular name: CD163, CD163 molecule
  • Gene family: CD molecules; Scavenger receptors; Scavenger receptor cysteine rich domain containing
  • Alias: M130; MM130; SCARI1
  • Alias: CD163 antigen


    • CD163 molecular target review


    CD163 is a protein that is encoded by the CD163 gene in humans. It belongs to the cysteine-rich B-type scavenger receptor family and contains an extracellular domain of 1048 amino acid residues, a single transmembrane segment, and a cytoplasmic tail with several splice variants. It is a scavenger receptor for the hemoglobin-haptoglobin complex and marks the monocyte/macrophage lineage. The soluble form of the receptor is present in plasma and is usually expressed as sCD163. sCD163 is produced by shedding of the extracellular domain of the membrane-bound receptor and is upregulated in a wide range of inflammatory diseases including cirrhosis, type 2 diabetes, macrophage activation syndrome, Gaucher's disease, sepsis, HIV infection, rheumatoid arthritis, and Hodgkin's lymphoma.


    Human CD163 Molecular Target Information


    Molecular name: CD163, CD163 molecule


    Alias:

    • cluster of differentiation 163
    • hemoglobin scavenger receptor
    • M130
    • macrophage-associated antigen
    • MM130
    • SCARI1
    • scavenger receptor cysteine-rich type 1 protein M130

    Gene sequence:NCBI_Gene: 9332

    Protein sequence:UniProtKB: Q86VB7


    Human CD163 target molecule function (prediction)


    Enables scaffold protein binding activity. Predicted to be involved in acute-phase response and endocytosis. Located in external side of plasma membrane. Biomarker of several diseases, including Ebola hemorrhagic fever; Whipple disease; fatty liver disease (multiple); leishmaniasis (multiple); and lung disease (multiple).


    Mouse Cd163 molecular target information


    Molecular name: Cd163, CD163 antigen


    Alias:

    • None


    Gene sequence:NCBI_Gene: 93671

    Protein sequence:


    Mouse Mouse Cd163 Target Molecular Function (Prediction)


    Predicted to enable scaffold protein binding activity and scavenger receptor activity. Predicted to act upstream of or within acute-phase response. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including gut; immune system; male reproductive gland or organ; olfactory lobe; and quadriceps femoris muscle. Orthologous to human CD163 (CD163 molecule).


    Rat Cd163 molecular target information


    Molecular name: Cd163, CD163 molecule

    Alias:

    • CD163 antigen
    • cluster of differentiation 163
    • LOC312701
    • scavenger receptor cysteine-rich type 1 protein M130

    Gene sequence:NCBI_Gene: 312701

    Protein sequence:


    Rat Cd163 target molecular function (prediction)


    Predicted to enable scaffold protein binding activity. Predicted to be involved in endocytosis. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Biomarker of uveitis. Orthologous to human CD163 (CD163 molecule).