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AHSG molecular target information overview


  • Molecular name: AHSG, alpha 2-HS glycoprotein
  • Gene family: Cystatins, type 4
  • Alias: FETUA; A2HS; HSGA
  • Alias: fetuin A


    • AHSG molecular target review


    Fetuin is a protein produced by the liver and secreted into the blood. They belong to binding proteins that mediate the transport and utilization of various substances in the blood. Human fetuin is also known as α2-HS glycoprotein (AHSG), α2-HS, A2HS, AHS, HSGA, and fetuin A. Experiments with knockout mice have shown that fetuin A is a potential inhibitor of systemic calcification. It plays an important role in free fatty acid-induced insulin resistance in the liver. In prediabetes, fetuin A predicts adverse glycemic outcomes. It is also associated with increased incidence of non-alcoholic fatty liver disease and cardiovascular disease. In sepsis and endotoxemia, it is a negative acute phase reactant, promotes wound healing, and has a neuroprotective effect in Alzheimer's disease. In obstructive pulmonary disease, Crohn's disease, and ulcerative colitis, decreased levels of fetuin A indicate an increased risk of active disease.


    Human AHSG Molecular Target Information


    Molecular name: AHSG, alpha 2-HS glycoprotein


    Alias:

    • A2HS
    • AHS
    • alpha-2-HS-glycoprotein
    • alpha-2-Z-globulin
    • APMR1
    • ba-alpha-2-glycoprotein
    • FETUA
    • fetuin A
    • fetuin-A
    • HSGA

    Gene sequence:NCBI_Gene: 197

    Protein sequence:UniProtKB: P02765


    Human AHSG target molecular function (prediction)


    Predicted to enable endopeptidase inhibitor activity. Involved in acute-phase response; positive regulation of phagocytosis; and regulation of inflammatory response. Located in Golgi apparatus. Implicated in alopecia-mental retardation syndrome 1; coronary artery disease; and type 2 diabetes mellitus. Biomarker of gestational diabetes; myocardial infarction; obesity; and type 2 diabetes mellitus.


    Mouse Ahsg molecular target information


    Molecular name: Ahsg, alpha-2-HS-glycoprotein


    Other Names:

    • Fetuin-A


    Gene sequence:NCBI_Gene: 11625

    Protein sequence:


    Mouse Ahsg Target Molecular Function (Prediction)


    Predicted to enable endopeptidase inhibitor activity and receptor signaling protein tyrosine kinase inhibitor activity. Involved in negative regulation of bone mineralization. Acts upstream of or within ossification. Predicted to be located in Golgi apparatus; collagen-containing extracellular matrix; and extracellular space. Predicted to be part of protein-containing complex. reproductive system; and skeletal musculature. Human ortholog(s) of this gene implicated in alopecia-mental retardation syndrome 1; coronary artery disease; and type 2 diabetes mellitus. Orthologous to human AHSG (alpha 2-HS glycoprotein).


    Rat Ahsg molecular target information


    Molecular name: Ahsg, alpha-2-HS-glycoprotein

    Alias:

    • 59 kDa bone sialic acid-containing protein
    • Aa2-066
    • alpha 2 HS-glycoprotein alpha 2 (fetuin)
    • BSP
    • fetuin-A
    • glycoprotein PP63
    • phosphorylated N-glycoprotein pp63
    • phosphorylated N-glycoprotein, pp63
    • pp63

    Gene sequence:NCBI_Gene: 25373

    Protein sequence:UniProtKB: P24090


    Rat Ahsg target molecular function (prediction)


    Enables receptor signaling protein tyrosine kinase inhibitor activity. Involved in several processes, including animal organ development; negative regulation of bone mineralization; and positive regulation of bone resorption. Located in collagen-containing extracellular matrix and extracellular space. Part of protein-containing complex. Human ortholog(s) of this gene implicated in alopecia-mental retardation syndrome 1; coronary artery disease; and type 2 diabetes mellitus. Orthologous to human AHSG (alpha 2-HS glycoprotein).