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CXCL16 molecular target information overview


  • Molecular name: CXCL16, CXC motif chemokine ligand 16
  • Gene family: Chemokine ligands; Scavenger receptors
  • Alias: SR-PSOX; CXCLG16; SRPSOX
  • Alias: CXC chemokine ligand 16; chemokine (CXC motif) ligand 16


    • CXCL16 molecular target review


    Chemokine (CXC motif) ligand 16 (CXCL16) is a small molecular weight cytokine belonging to the CXC chemokine family. It is composed of 254 amino acids and is a type I membrane protein. The gene for human CXCL16 is located on chromosome 17. CXCL16 is produced by dendritic cells in the T cell zone of lymphoid organs and cells in the red pulp of the spleen. Inflammatory cytokines IFN-γ and TNF-α can induce the expression of CXCL16. CXCL16 interacts with the chemokine receptor CXCR6 (also known as Bonzo). Folic acid injection can force CXCL 16 to undergo methylation, inducing high levels of methylation of the CXCL 16 gene promoter in the colon, ileum, and lungs, and also causing iNKT cells to accumulate in these tissues.


    Human CXCL16 Molecular Target Information


    Molecular name: CXCL16, CXC motif chemokine ligand 16


    Alias:

    • CXC motif chemokine 16
    • chemokine (CXC motif) ligand 16
    • CXC chemokine ligand 16
    • CXCLG16
    • scavenger receptor for phosphatidylserine and oxidized low density lipoprotein
    • small-inducible cytokine B16
    • SR-PSOX
    • SRPSOX
    • transmembrane chemokine CXCL16

    Gene sequence:NCBI_Gene: 58191

    Protein sequence:UniProtKB: Q9H2A7


    Human CXCL16 target molecular function (prediction)


    Enables chemokine activity. Involved in several processes, including positive regulation of cell growth; response to interferon-gamma; and response to tumor necrosis factor. Located in extracellular space. Biomarker of COVID-19 and systemic scleroderma.


    Mouse Cxcl16 molecular target information


    Molecular name: Cxcl16, chemokine (CXC motif) ligand 16


    Alias:

    • 0910001K24Rik
    • AV290116
    • BB024863
    • expressed sequence AV290116
    • expressed sequence BB024863
    • RIKEN cDNA 0910001K24 gene
    • Scavenger Receptor
    • SR-PSOX
    • SR-PSOX/CXCL16


    Gene sequence:NCBI_Gene: 66102

    Protein sequence:


    Mouse Cxcl16 target molecular function (prediction)


    Enables chemokine activity; low-density lipoprotein particle receptor activity; and scavenger receptor activity. Involved in T cell chemotaxis and cellular response to lipopolysaccharide. Located in extracellular space. Is integral component of membrane. Is expressed in bladder; female associated reproductive structure; hindbrain meninges; male associated reproductive structure; and spinal cord meninges. Orthologous to human CXCL16 (CXC motif chemokine ligand 16).


    Rat Cxcl16 molecular target information


    Molecular name: Cxcl16, CXC motif chemokine ligand 16

    Alias:

    • CXC motif chemokine 16
    • chemokine (CXC motif) ligand 16
    • similar to chemokine (CXC motif) ligand 16
    • small-inducible cytokine B16
    • transmembrane chemokine CXCL16

    Gene sequence:NCBI_Gene: 497942

    Protein sequence:


    Rat Cxcl16 target molecular function (prediction)


    Predicted to enable chemokine activity; low-density lipoprotein particle receptor activity; and scavenger receptor activity. Predicted to be involved in several processes, including T cell chemotaxis; cellular response to lipopolysaccharide; and response to interferon-gamma. Predicted to be integral component of membrane. Predicted to be active in extracellular space. Orthologous to human CXCL16 (CXC motif chemokine ligand 16).