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ADIPOQ molecular target information overview


  • Molecular name: ADIPOQ, adiponectin, C1Q and collagen domain containing
  • Gene family: C1q and TNF related
  • Alias: ACRP30; apM1; GBP28; adiponectin
  • Previous name: ACDC
  • Alias: adipose most abundant gene transcript 1; adiponectin precursor; adipocyte, C1Q and collagen domain containing


    • ADIPOQ molecular target review


    Adiponectin, also known as adipocyte complement-related protein 30 (Acrp30), is involved in regulating glucose levels and fatty acid breakdown. It assembles into different complexes including trimers, hexamers, and higher-order oligomeric structures, which may affect biological activity. Adiponectin is a protein hormone that regulates many metabolic processes, including glucose regulation and fatty acid oxidation. Adipose tissue (and the placenta during pregnancy) specifically secretes adiponectin into the blood, so adiponectin is abundant in plasma relative to many other hormones. Adiponectin may have anti-atherosclerotic and anti-inflammatory effects, negatively regulating the growth of granulocyte-monocyte progenitor cells and the production of TNF-α in macrophages. Monitoring serum adiponectin levels in several pathological conditions, such as type 2 diabetes, obesity, atherosclerosis, and non-alcoholic fatty liver disease, may provide more detailed insights into our understanding of adiponectin.


    Human ADIPOQ Molecular Target Information


    Molecular name:ADIPOQ, adiponectin, C1Q and collagen domain containing


    Alias:

    • 30 kDa adipocyte complement-related protein
    • ACDC
    • ACRP30
    • adipocyte complement-related 30 kDa protein
    • adiponectin
    • adipose most abundant gene transcript 1 protein
    • adipose specific collagen-like factor
    • ADIPQTL1
    • ADPN
    • APM-1
    • APM1
    • GBP28
    • gelatin-binding protein 28

    Gene sequence:NCBI_Gene: 9370

    Protein sequence: UniProtKB: Q15848


    Human ADIPOQ target molecular function (prediction)


    Enables hormone activity; protein homodimerization activity; and sialic acid binding activity. Involved in several processes, including negative regulation of cell communication; negative regulation of cell differentiation; and negative regulation of macromolecule metabolic process. Located in cell surface and extracellular space. Part of collagen-containing extracellular matrix. Implicated in several diseases, including carcinoma (multiple); cardiovascular system disease (multiple); non-alcoholic fatty liver disease; primary open angle glaucoma; mellitus. Biomarker of several diseases, including autoimmune disease (multiple); cardiovascular system disease (multiple); diabetes mellitus (multiple); fatty liver disease (multiple); and inflammatory bowel disease (multiple).


    Mouse Adipoq molecular target information


    Molecular name:Adipoq, adiponectin, C1Q and collagen domain containing


    Alternate names:

    • Acdc
    • Acrp30
    • Ad
    • adipo
    • adipocyte complement related protein
    • adipocyte, C1Q and collagen domain containing
    • adiponectin
    • apM1
    • APN
    • GBP28


    Gene sequence:NCBI_Gene: 11450

    Protein sequence:


    Mouse Adipoq target molecular function (prediction)


    Enables hormone activity and identical protein binding activity. Involved in several processes, including detection of oxidative stress; negative regulation of cold-induced thermogenesis; and regulation of protein serine/threonine kinase activity. Acts upstream of or within with a positive effect on gene expression. including adipose tissue; axial musculature; gut; male reproductive gland or organ; and serum. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); cardiovascular system disease (multiple); non-alcoholic fatty liver disease; primary open angle glaucoma; and type 2 diabetes mellitus. Orthologous to human ADIPOQ (adiponectin, C1Q and collagen domain containing).


    Rat Adipoq molecular target information


    Molecular name:Adipoq, adiponectin, C1Q and collagen domain containing

    Alias:

    • Acdc
    • Acrp30
    • Adid
    • adipocyte complement related protein of 30 kDa
    • adiponectin
    • adiponectin d

    Gene sequence:NCBI_Gene: 246253

    Protein sequence:


    Rat Adipoq target molecular function (prediction)


    Enables identical protein binding activity. Involved in several processes, including cellular response to organonitrogen compound; positive regulation of glycogen (starch) synthase activity; and positive regulation of protein phosphorylation. Located in extracellular space. Part of protein-containing complex. Used to study brain infarction. Biomarker of several diseases, including end stage renal disease; fatty liver disease (multiple); glucose metabolism disease (multiple); hyperthyroidism; and obesity. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); cardiovascular system disease (multiple); non-alcoholic fatty liver disease; primary open angle glaucoma; and type 2 diabetes mellitus. Orthologous to human ADIPOQ (adiponectin, C1Q and collagen domain containing).